Calbotol

Indications

The combination of Calcium Citrate and Calcitriol is prescribed to prevent or treat low blood calcium levels in individuals with insufficient dietary calcium intake. It is used to manage conditions stemming from low calcium levels such as osteoporosis, osteomalacia (softening of bones), rickets, hypoparathyroidism, and latent tetany. Additionally, it may be recommended for ensuring adequate calcium intake in specific patient groups, such as postmenopausal women.

Composition

Each tablet contains:

• Calcium Citrate USP 1200 mg (equivalent to Calcium 252 mg)
• Calcitriol EP 0.25 mcg

Pharmacology

Calcium is crucial for the normal functioning of nerves, cells, muscles, and bones. Insufficient blood calcium prompts the body to extract calcium from bones, weakening them. Calcium citrate is efficiently absorbed on an empty stomach and is less likely to cause constipation. It also requires less stomach acid for absorption.

Calcitriol, the active form of vitamin D3, enhances calcium absorption in the intestines and regulates bone mineralization. In patients with chronic kidney failure, where calcitriol production is impaired, supplementation helps normalize calcium and phosphate absorption, thereby improving bone health.

Dosage & Administration

Take 1-4 tablets daily, with or without food, as per clinical recommendation or directed by a healthcare professional.

Interactions

Calcium may reduce the absorption of certain medications like tetracyclines and quinolones. It can also interact with corticosteroids, thiazide diuretics, and other drugs affecting calcium levels.

Contraindications

This medication is contraindicated in patients with hypercalcemia, hypercalciuria, and hypophosphatemia.

Side Effects

Common side effects may include constipation, nausea, abdominal pain, and rarely, hypercalcemia or hypercalciuria.

Pregnancy & Lactation

Use under medical supervision during pregnancy and lactation (Category C).

Precautions & Warnings

Use with caution in patients with conditions such as hypercalcemia, malabsorption syndromes, kidney or liver diseases, certain immune disorders, and specific bowel diseases.

Therapeutic Class

Specific mineral and vitamin combined preparations.

Storage Conditions

Store in a cool, dry place below 25°C, protected from light and moisture. Keep out of reach of children.