Brodil Syrup

Indications

Brodil is a bronchodilator designed for managing the following conditions:

• Asthma
• Chronic Bronchitis
• Emphysema
• Other respiratory conditions involving airway obstruction

Note: Use medication only as prescribed by a registered physician.

Pharmacology

Salbutamol, a synthetic sympathomimetic agent, primarily activates beta-2 adrenergic receptors. This mechanism promotes relaxation of bronchial smooth muscles, leading to bronchodilation. As a result, pulmonary function improves, as evidenced by spirometric evaluations.

Dosage & Administration

Salbutamol Tablets or Syrup

Children:

• 2–6 years: 2.5 ml syrup, 3–4 times daily
• 6–12 years: 5 ml syrup, 3–4 times daily
• Over 12 years: 5–10 ml syrup (or 2–4 mg tablets), 3–4 times daily

Adults:

• 2–4 mg tablet, 3–4 times daily (maximum single dose: 8 mg tablet)

Salbutamol Respirator Solution

To be used with a nebulizer under medical supervision. Not for injection or oral consumption.

• Intermittent Administration:
  • Adults: 0.5–1.0 ml solution diluted with 2–4 ml saline, inhaled over 10 minutes, up to 4 times daily.
  • Children: 0.5 ml solution diluted to 2–4 ml saline. Some may require up to 1 ml per session, up to 4 times daily.
• Continuous Administration:
  • 1–2 ml solution diluted to 100 ml with saline, administered using a nebulizer. Oxygen supplementation may be required in cases of hypoventilation.

Salbutamol Nebulizer Solution

• Adults & Elderly: 2.5–5 mg up to 4 times a day. Maximum dose: 40 mg/day under hospital supervision.
• Children: 2.5 mg up to 4 times daily, with potential increases to 5 mg as needed.

Salbutamol Inhalation Capsule

• Adults: 1–2 capsules (200 mcg each) every 4–6 hours. Not to exceed recommended doses.
• Children (4+ years): 1 capsule per dose, 3–4 times daily. Dose may increase to 2 capsules if needed.

Exercise-Induced Asthma

• Adults: 400 mcg
• Children: 200 mcg, taken 15–30 minutes before exercise

Side Effects

Common side effects of Brodil include:

• Fine tremors (particularly in the hands)
• Muscle cramps
• Palpitations
• Tachycardia
• Tension, headaches, and peripheral vasodilation (with high doses)

Pregnancy & Lactation

Salbutamol should only be used during pregnancy if the benefits outweigh potential risks to the fetus. It’s unclear whether the drug passes into breast milk, so consult your doctor regarding its use while nursing.

Precautions & Warnings

Exercise caution when prescribing Brodil for patients with:

• Hyperthyroidism
• Cardiovascular disease or hypertension
• Diabetes
• Glaucoma
• Aneurysms
  High doses may cause hypokalemia, increasing the risk of digitalis-induced cardiac arrhythmia. Prolonged use of high doses may lead to resistance or tachyphylaxis.

Overdose Management

Symptoms of overdose include angina, nausea, vomiting, headache, and tremors. Treatment involves using a cardio-selective beta-blocker cautiously, especially in patients with a history of bronchospasm.

Therapeutic Class

Short-acting beta-2 adrenoceptor stimulants

Storage Instructions

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.