Bisopro 2.5 Plus

Indications

Bisoprolol plus Hydrochlorothiazide is prescribed for managing hypertension.

Pharmacology

This combination leverages the individual and synergistic effects of Bisoprolol Fumarate and Hydrochlorothiazide for effective hypertension treatment. The addition of Hydrochlorothiazide at 6.25 mg enhances the antihypertensive action of Bisoprolol. Notably, this combination results in a lower incidence of hypokalemia compared to higher doses of Hydrochlorothiazide alone. Bisoprolol acts as a selective beta-1 blocker, while Hydrochlorothiazide is a diuretic that promotes sodium and chloride excretion by affecting renal tubular functions.

Dosage & Administration

Adults: Initiate treatment with one tablet of 2.5/6.25 mg once daily. Gradually titrate the dosage every 14 days, up to a maximum of 20/12.5 mg once daily, based on individual response.
Children: Safety and efficacy in those under 18 have not been established.
Renal/Hepatic Impairment: Start with 5 mg and adjust cautiously.
Elderly: Generally, no dosage adjustment is necessary unless significant renal or hepatic issues are present.
Consult a registered physician before use.

Interaction

Bisopro Plus may enhance the effects of other antihypertensive medications. Avoid combining it with other beta-blockers. Monitor closely if using with catecholamine-depleting drugs or calcium channel blockers.

Contraindications

Not recommended for patients with cardiogenic shock, overt cardiac failure, severe AV block, marked bradycardia, anuria, or hypersensitivity to components.

Side Effects

Typically well tolerated, side effects may include fatigue, dizziness, headache, bradycardia, and gastrointestinal disturbances.

Pregnancy & Lactation

Pregnancy: Category C; use only if benefits outweigh risks.
Nursing Mothers: Not studied; thiazides are found in breast milk. Weigh the importance of the drug against potential risks to infants.

Precautions & Warnings

Monitor for signs of fluid and electrolyte imbalance, especially in patients with hyperuricemia or gout. Gradual withdrawal over two weeks is advised.

Overdose Effects

Overdose symptoms may include bradycardia, hypotension, and, in severe cases, delirium or respiratory arrest. Monitor for cardiovascular and electrolyte disturbances.

Therapeutic Class

Combined antihypertensive agents.

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.