Beuflox Eye/Ear Drop

Indications

Beuflox 0.3% ophthalmic solution is specifically designed to treat corneal ulcers, conjunctivitis, and blepharitis caused by bacteria susceptible to this medication.

• Consult a registered healthcare professional before using this medication.

Composition

Each milliliter of Beuflox eye drops contains:

• Active Ingredient: Ciprofloxacin Hydrochloride BP, equivalent to Ciprofloxacin 3 mg.
• Preservative: Benzalkonium Chloride 0.06 mg.

Pharmacology

Ciprofloxacin exhibits in vitro activity against a broad spectrum of both Gram-negative and Gram-positive bacteria. It is a bactericidal agent that functions by inhibiting the A subunits of DNA gyrase (topoisomerase), a crucial enzyme for bacterial DNA replication.

Dosage & Administration

• For Corneal Ulcers:
  • Administer 2 drops into the affected eye every 15 minutes for the first six hours.
  • Follow with 2 drops every 30 minutes for the remainder of the first day.
  • On the second day, instill 2 drops hourly into the affected eye.
  • From days three to fourteen, administer 2 drops every four hours. Treatment may continue beyond 14 days if corneal re-epithelialization has not occurred.
• For Bacterial Conjunctivitis/Blepharitis:
  • Apply 1 drop into the conjunctival sac(s) every two hours for two days, followed by 1 drop every four hours for the subsequent five days.
• Pediatric Use: Safety and effectiveness in children under one year have not been established.

• Consult a registered healthcare professional before using this medication.

Interactions

While specific drug interaction studies with Beuflox have not been performed, systemic use of certain quinolones has been associated with increased plasma levels of theophylline, altered caffeine metabolism, enhanced effects of oral anticoagulants like warfarin, and transient increases in serum creatinine levels in patients concurrently receiving cyclosporine.

Contraindications

Beuflox should not be used in individuals with a known hypersensitivity to Ciprofloxacin or any of its components. A history of hypersensitivity to other quinolones, such as Nalidixic acid, may also contraindicate its use.

Side Effects

Commonly reported side effects include local burning sensations or discomfort. In studies concerning corneal ulcers with frequent administration, approximately 17% of patients experienced white crystalline precipitates. Less common reactions (occurring in fewer than 10% of patients) include:

• Lid margin crusting
• Crystals/scales
• Foreign body sensation
• Itching
• Conjunctival hyperemia
• Altered taste sensation post-instillation

Rare side effects (occurring in less than 1% of patients) include:

• Corneal staining
• Keratopathy/Keratitis
• Allergic reactions
• Lid edema
• Tearing
• Photophobia
• Corneal infiltrates
• Nausea
• Decreased vision

Pregnancy & Lactation

There are insufficient well-controlled studies on the use of Ciprofloxacin ophthalmic solution in pregnant women. It should be used during pregnancy only if the potential benefits outweigh the risks to the fetus.

Precautions & Warnings

General precautions include the risk of overgrowth of non-susceptible organisms, including fungi, with prolonged use of anti-infectives. If a super-infection occurs, discontinue use and seek alternative treatment. Beuflox should be stopped at the first sign of a skin rash or any hypersensitivity reaction.

Overdose Effects

In case of topical overdose, excess Beuflox eye drops can be rinsed from the eyes using warm tap water.

Therapeutic Class

• Aural Anti-bacterial preparations
• Ophthalmic antibacterial medications

Storage Conditions

Store at room temperature, away from light. It is recommended not to use the product more than one month after the bottle has been opened.