Indications
For individuals with chronic obstructive pulmonary disease (COPD), this medication aids in maintaining respiratory function.
Pharmacology
- Aclidinium Bromide: Acts as a long-acting anti-muscarinic agent, facilitating bronchodilation by inhibiting M3 receptors.
- Formoterol Fumarate: A selective beta2-adrenergic receptor agonist, promoting bronchial relaxation by stimulating intracellular adenyl cyclase.
Dosage & Administration
Administered via oral inhalation using a revolizer device, with a recommended dosage of 400 mcg/12 mcg, twice daily.
Interactions
- Caution advised when combining with other adrenergic agents or certain medications like xanthine derivatives and diuretics.
- Avoid simultaneous use with monoamine oxidase inhibitors, tricyclic antidepressants, and anticholinergics.
Contraindications
Avoid in patients with asthma not receiving inhaled corticosteroids or with hypersensitivity to the ingredients.
Side Effects
Common adverse reactions include upper respiratory tract infections and headaches.
Pregnancy & Lactation
Limited data available; use caution during pregnancy and lactation.
Precautions & Warnings
- Long-acting beta2-adrenergic agonists may increase asthma-related risks.
- Not suitable for acute COPD exacerbations or in combination with other LABA-containing medications.
Therapeutic Class
Combined bronchodilators.
Storage Conditions
Store below 25°C, protected from light and moisture, and out of reach of children.
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