Acifix 20

Indications

Acifix Gastro-resistant tablets are used for:

• Treating active duodenal and benign gastric ulcers.
• Managing symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD).
• Long-term maintenance of GERD.
• Alleviating symptoms of moderate to severe GERD.
• Addressing Zollinger-Ellison Syndrome.
• Eradicating Helicobacter pylori in peptic ulcer disease as part of a combination therapy.

Pharmacology

Acifix, containing Rabeprazole, works as a proton pump inhibitor by blocking the H+/K+-ATPase enzyme on the gastric parietal cells’ surface. This action suppresses gastric acid secretion effectively. Rabeprazole is known for its rapid onset and safety compared to other acid-reducing medications.

Dosage & Administration

• For ulcers and GERD: 20 mg once daily in the morning. Healing times vary, with some cases needing up to an additional 4-6 weeks.
• Long-term GERD management: Maintenance dose of 10-20 mg daily.
• Severe GERD symptoms: 10 mg daily; can be adjusted based on symptom control.
• Pediatric dosing: 5-10 mg daily depending on weight.
• Zollinger-Ellison Syndrome: Start with 60 mg daily, adjustable to 120 mg/day.

Administration: Take tablets whole, before meals, and not chewed or crushed.

Interactions

Avoid combining Acifix with ketoconazole, itraconazole, or atazanavir due to potential interactions. No issues with liquid antacids.

Contraindications

Do not use if allergic to Rabeprazole, its components, or other proton pump inhibitors. Not suitable for use during pregnancy or breastfeeding.

Side Effects

Common side effects include headache, dizziness, gastrointestinal discomfort, and dry mouth. Serious effects are rare but can include blood dyscrasias and hepatic enzyme abnormalities.

Pregnancy & Lactation

Category C: Use only if benefits outweigh risks. Caution advised during breastfeeding.

Precautions & Warnings

• Long-term use: Regular monitoring required for bone health and potential side effects.
• Potential risks: May increase fracture risk, affect vitamin B12 absorption, and rarely cause subacute cutaneous lupus erythematosus (SCLE).
• Special considerations: No dosage adjustment needed for renal or hepatic impairment.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.