Diasulin 50/50 100iu

Indications

Diasulin Injection is prescribed for:

• Managing type 1 diabetes in all patients.
• Treating type 2 diabetes when diet and/or oral hypoglycemic agents fail to provide adequate control.
• Stabilizing diabetes in cases such as diabetic ketoacidosis, hyperosmolar non-ketotic syndrome, or during stressful conditions like severe infections or major surgeries in diabetic patients.
• Controlling gestational diabetes.

Always follow the advice of a registered physician when using this medication.

Composition

30/70: Each ml of suspension contains 100 IU of Human Insulin (rDNA) USP, equivalent to 3.47 mg, formulated as 30% Regular Insulin Human and 70% Isophane Insulin Human.

50/50: Each ml of suspension contains 100 IU of Human Insulin (rDNA) USP, equivalent to 3.47 mg, formulated as 50% Regular Insulin Human and 50% Isophane Insulin Human.

Pharmacology

The glucose-lowering action of insulin is due to its ability to facilitate glucose uptake in muscle and fat cells while suppressing glucose output from the liver. Insulin’s half-life in the bloodstream is just a few minutes, with minimal plasma protein binding.

Typical action profile after subcutaneous injection:

• Onset of action: Within 30 minutes.
• Peak effect: Achieved in 1-3 hours.
• Duration: Approximately 18-24 hours.

Dosage

The dosage is individualized and determined by the physician based on the patient’s needs.

• Type 1 Diabetes: Total daily insulin requirements typically range from 0.5 to 1.0 IU/kg. Pre-pubertal children may need 0.7 to 1.0 IU/kg.
• Type 2 Diabetes (Initial Dose): Generally lower, ranging from 0.3 to 0.6 IU/kg/day.
• Special Considerations: Insulin needs may increase in cases of insulin resistance (e.g., puberty or obesity) and decrease during partial remission.

Insulin injections should be followed by a carbohydrate-containing meal or snack within 30 minutes.

Administration

• Typically injected subcutaneously into the abdominal wall for faster absorption. Alternate sites include the thigh, gluteal region, or deltoid.
• Rotate injection sites within the same anatomical region to prevent lipodystrophy.

Dosage Adjustments

• Insulin needs may rise during illnesses, infections, or fever.
• Patients with renal or hepatic impairments may require lower doses.
• Physical activity and dietary changes may also necessitate dosage adjustments.
• Switching insulin types or brands should be supervised by a doctor.

Usage Instructions

Before Using:

• Confirm you have the correct insulin type.
• Inspect the cartridge and rubber plunger for damage.
• Disinfect the rubber membrane before use.

Mixing:

• Gently move the cartridge up and down to mix the insulin until it appears uniformly white and cloudy.
• Repeat this process before each injection.

Injecting:

• Administer insulin under the skin using the method described in the delivery system manual.
• Keep the needle under the skin for at least 6 seconds to ensure full dose delivery.
• Remove the needle immediately after injection to prevent leakage.

Interactions

Certain substances may influence insulin requirements:

• Decrease insulin needs: Oral hypoglycemic agents, MAO inhibitors, beta-blockers, ACE inhibitors, salicylates, and alcohol.
• Increase insulin needs: Thiazides, glucocorticoids, thyroid hormones, beta-sympathomimetics, growth hormones, and danazol.

Beta-blockers may mask hypoglycemia symptoms and delay recovery. Alcohol can prolong the hypoglycemic effect.

Contraindications

• Not suitable for patients with hypoglycemia or known hypersensitivity to insulin or its components.

Side Effects

• Common: Hypoglycemia, lipodystrophy at injection sites.
• Rare but serious: Generalized hypersensitivity reactions, including skin rash, angioneurotic edema, and respiratory issues.
• Transient effects: Edema during the initiation of insulin therapy.

Pregnancy & Lactation

• Insulin therapy is safe during pregnancy as it does not cross the placental barrier.
• Insulin requirements may fluctuate during different trimesters and normalize postpartum.
• Breastfeeding mothers can safely continue insulin therapy.

Precautions & Warnings

• Inadequate insulin dosage may lead to hyperglycemia or diabetic ketoacidosis, which can be life-threatening.
• Transitioning between insulin types requires medical supervision.
• Inspect insulin for clumps or frost-like particles and avoid using if these are present.

Overdose Effects

• Mild hypoglycemia can be managed with glucose or sugary foods.
• Severe cases may require Glucagon injection or IV glucose administration by medical professionals.

Storage Conditions

• Store between 2°C and 8°C (refrigerated).
• Do not freeze insulin.
• Protect from light, heat, and sunlight.
• Once opened, keep the cartridge at room temperature and use within 6 weeks if stored below 25°C, or within 4 weeks if stored below 30°C.