Progavi

Indications:

Progavi is recommended for the relief of:

• Acid reflux
• Heartburn
• Indigestion
• Gas associated with acid reflux
• Pregnancy-related heartburn
• All forms of epigastric and retrosternal discomfort where gastric reflux is the root cause.

Pharmacology:

Progavi is a combination of two antacids (Calcium Carbonate and Sodium Bicarbonate) and an alginate (Sodium Alginate). This dual-action suspension works by:

1. Neutralizing excess stomach acid to alleviate pain and discomfort.
2. Creating a protective layer over stomach contents, soothing the burning sensation in the chest.

Its action is primarily physical, not reliant on absorption into the bloodstream. Upon ingestion, the product interacts with stomach acid to form a near-neutral pH alginic acid gel (raft) that shields the esophagus from acid reflux for up to 4 hours. In severe cases, the raft may be refluxed itself, offering further protection. Additionally, the raft can trap bile and pepsin, further protecting the esophagus.

Calcium Carbonate quickly neutralizes stomach acid for fast relief, enhanced by Sodium Bicarbonate’s neutralizing properties.

Dosage & Administration:

• Oral Suspension:
  • Adults and children over 12 years: 10-20 mL after meals and at bedtime, up to four times daily.
  • Children aged 6-12 years: 5-10 mL after meals and at bedtime, up to four times daily.
  • Children under 6 years: Not recommended.
  • Elderly: No dosage adjustments necessary.
• Chewable Tablets:
  • Adults and children over 12 years: 2-4 tablets after meals and before bedtime, up to four times daily.
  • Children under 12 years: Use only under medical supervision.

Hepatic Impairment: No dosage adjustment required.
Renal Impairment: Caution is advised for those on a strict low-sodium diet.

Drug Interactions:

It’s advisable to maintain a 2-hour gap between Progavi and other medications like Tetracyclines, Digoxin, Fluoroquinolones, Iron supplements, Ketoconazole, Beta-blockers, and others.

Contraindications:

Progavi should not be used by individuals with known hypersensitivity to its ingredients or excipients.

Side Effects:

While effective, some users may experience minor side effects such as constipation, gas, stomach cramps, or belching. In case of significant swelling or discomfort, consult a healthcare provider.

Pregnancy  & Lactation:

• Pregnancy: Studies in over 500 pregnant women indicate that Progavi is safe to use without causing harm to the fetus.
• Breastfeeding: No adverse effects have been observed in breastfed infants. Progavi can be used during breastfeeding.
• Fertility: Pre-clinical studies indicate that the ingredients in Progavi do not affect fertility or reproduction.

Precautions & Warnings:

• Each 20 mL dose contains 254.5 mg of sodium, which should be considered in patients on a low-sodium diet, especially those with heart failure or renal impairment.
• It also contains 260 mg of calcium per 20 mL, so use caution in patients with hypercalcemia or a history of calcium-related kidney stones.
• Aspartame in the product means it should not be taken by those with phenylketonuria.
• Prolonged use (over 7 days) without medical supervision is not recommended.

Overdose:

In case of overdose, symptomatic treatment is advised. Symptoms may include abdominal bloating.

Therapeutic Class:

Antacids

Storage Conditions:

Store in a cool, dry place below 30°C, away from light and out of children’s reach. Do not refrigerate or freeze.