Penvik Forte PFS
84.43৳ Pcs
- Effective treatment for a range of bacterial infections, from ear and throat ailments to skin conditions
- Phenoxymethyl penicillin-based medications ensure convenient and reliable solutions
- Optimal absorption and acid stability for maximum efficacy
- Trust us for quality care and prompt relief
Brand |
Square Pharmaceuticals PLC |
---|---|
Generics |
Phenoxymethyl Penicillin [Penicillin V] |
Type |
Suspension |
Size |
100 ML |
Indications
Addressing mild to moderately severe bacterial infections caused by penicillin-susceptible pathogens, responsive to oral penicillin therapy, including:
- Infections affecting the ear, nose, and throat regions like tonsillitis, pharyngitis, laryngitis, otitis media, and sinusitis.
- Lower respiratory tract infections such as bronchitis, pneumonia, and bronchopneumonia.
- Infections resulting from beta-hemolytic streptococci of group A, like scarlet fever, erysipelas, and rheumatic fever.
- Skin infections such as pyoderma, furunculosis, phlegmon, erysipeloid, and erythema migrans, provided the microorganisms are susceptible to penicillin.
- Bacterial lymphadenitis and lymphangitis.
- Buccal cavity, gum, or jaw infections, including inflammatory infiltrates, delayed dentition stages II and III, antral fistulae, and secondary bacterial infections following virus-induced gingivitis or stomatitis. For scarlet fever prophylaxis and to prevent rheumatic fever recurrences. Also used for prophylaxis against infection after dental and oral surgical procedures or dental extractions in specific high-risk patients (e.g., those with congenital cardiac defects, artificial heart valves, or rheumatic endocarditis). In some cases, combination therapy with another appropriate antibiotic may be necessary.
Pharmacology
Phenoxymethyl penicillin, also known as penicillin V, remains stable in acidic conditions and is absorbed primarily from the upper part of the small intestine. Among various forms, the potassium salt of phenoxymethyl penicillin demonstrates optimal absorption. While it can be administered with meals, maximum absorption occurs when taken orally at least an hour before or two hours after eating. Phenoxymethyl penicillin offers a convenient approach to treating Gram-positive infections and boasts an advantage over penicillin G due to its resistance to gastric acid inactivation.
Dosage
The dosage of Phenoxymethyl penicillin should be adjusted based on the sensitivity of the causative microorganism and the severity of the infection, and should be tailored to the patient’s clinical response.
- Adults: 250-500 mg every six hours.
- Children (over 1 year): 125-250 mg every six hours. For suspension: 1-2 teaspoonfuls (5-10 ml) every six hours for 125 mg/5 ml powder, and ½-1 teaspoonful (2.5-5 ml) every six hours for 250 mg/5 ml powder.
- Infants (below 1 year): 62.5-125 mg every six hours. For suspension: ½-1 teaspoonful (2.5-5 ml) every six hours, or as prescribed by the physician. Phenoxymethyl penicillin is preferably taken on an empty stomach, ideally at least an hour before or two hours after meals.
Administration
Phenoxymethyl Penicillin is most effective when taken on an empty stomach, preferably one hour before meals. Tablets should be swallowed whole with ample liquid. Prior to each use of the syrup, vigorously shake the bottle.
Interaction
Food: Concurrent intake of food slows the absorption rate. Thus, Penvik is best taken on an empty stomach, ideally an hour before meals, to maximize absorption.
Drug interactions: Concurrent administration of penicillins may elevate methotrexate levels in serum, intensifying its toxic effects. Hence, monitoring serum methotrexate levels is imperative. If diarrhea occurs during Penvik treatment, it may disrupt the absorption of other orally administered drugs, potentially compromising their efficacy. Combining penicillins with bacteriostatic chemotherapeutics or antibiotics (e.g., tetracyclines, chloramphenicol) may weaken or nullify penicillins’ activity. Probenecid’s concurrent use inhibits the renal excretion of penicillins. Concurrent administration of indomethacin, phenylbutazone, salicylates, or sulfinpyrazone may elevate and prolong phenoxymethylpenicillin serum levels. Administering penicillins may transiently reduce plasma concentrations of estrogens and gestagens, rendering oral contraceptives less effective. Intestinal sterilization with aminoglycosides (e.g., neomycin) can reduce phenoxymethylpenicillin absorption. Combining penicillins with oral anticoagulants (e.g., warfarin) may prolong prothrombin time/INR. Penicillins may interfere with non-enzymatic urine glucose determinations and urobilinogen tests, yielding false-positive results.
Contraindications
Phenoxymethyl Penicillin is contraindicated in patients with hypersensitivity to penicillins or any of its excipients. Avoid administering it to patients with severe gastrointestinal disorders accompanied by vomiting and diarrhea.
Side Effects
Occasional hypersensitivity reactions involving the skin (e.g., urticaria, morbilliform or scarlatiniform rashes, pruritus), eosinophilia, or more severe allergic reactions like drug fever, vasculitis, serum sickness, or interstitial nephritis may occur. Anaphylactic or anaphylactoid reactions, accompanied by angioneurotic edema, laryngeal edema, bronchial spasms, and shock, are possible. In such cases, treatment must cease immediately. Skin rashes or mucous membrane inflammation, particularly in the oral region (stomatitis), may occur occasionally, along with dry mouth and taste disturbances. Rarely, severe bullous skin reactions, gastrointestinal disturbances, including nausea, vomiting, abdominal pain, loose stools, or diarrhea, may develop. Diarrhea may indicate enterocolitis, including pseudomembranous colitis (often due to Clostridium difficile), necessitating immediate cessation of Penvik administration and prompt medical attention. Changes in blood parameters, such as leukopenia, granulocytopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, and myelosuppression, may occur, particularly with high doses and prolonged administration. Spirochetal infection treatment may trigger Herxheimer’s reaction. Drug-induced aseptic meningitis is possible in isolated cases. Transient tooth discoloration may occur rarely during Penvik treatment. Prolonged antibiotic administration may foster resistant microorganisms. Beta-lactams may heighten encephalopathy risk, especially in cases of overdose or renal impairment.
Pregnancy & Lactation
Phenoxymethylpenicillin crosses the placenta and enters breast milk in minimal amounts. It may be used during pregnancy for appropriate indications and throughout lactation. However, infants may experience diarrhea and yeast colonization of mucous membranes.
Precautions & Warnings
Consider potential cross-allergy between cephalosporins and penicillins. Patients with heart diseases or significant electrolyte imbalances may require potassium content considerations of Penvik. Beta-lactams may increase encephalopathy risk, especially with overdose or renal impairment. Monitor patients regularly for changes in their condition during prolonged antibiotic use, as it may promote resistant microorganisms. Patients with diabetes mellitus should consider the sugar content of Penvik syrup. No impairment of driving or operating machinery has been reported. However, patients experiencing adverse reactions like encephalopathy should refrain from operating machinery or driving.
Overdose Effects
Phenoxymethylpenicillin exhibits low toxicity and has a broad therapeutic range. Single oral doses, even multiples of therapeutic doses, do not cause acute toxicity. Encephalopathy risk exists with beta-lactam antibiotic administration, particularly in cases of overdose or renal impairment. Specific measures beyond discontinuing the medication are unnecessary. Haemodialysis can eliminate phenoxymethylpenicillin if necessary.
Therapeutic Class
Benzylpenicillin & Phenoxymethyl penicillin
Storage Conditions
Store in a cool, dry place, shielded from light.
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