Trupan 20

Indications

Trupan is prescribed for conditions where reducing stomach acid is beneficial, including:

• Peptic ulcer diseases
• Gastroesophageal reflux disease (GERD)
• Ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs)
• Eradication of Helicobacter pylori (in combination with antibiotics)
• Zollinger-Ellison Syndrome

Pharmacology

Pantoprazole, the active ingredient in Trupan, is a proton pump inhibitor that reduces gastric acid production. It binds covalently to the H+/K+ ATPase enzyme system on the surface of gastric parietal cells, effectively inhibiting both basal and stimulated acid secretion for over 24 hours.

Dosage & Administration

Oral Administration:

• Benign Gastric Ulcer: 40 mg once daily in the morning for 4 weeks; extend another 4 weeks if necessary.
• Gastroesophageal Reflux Disease (GERD): 20-40 mg once daily in the morning for 4 weeks; continue for another 4 weeks if required. Maintenance dose: 20 mg daily, can be increased to 40 mg daily.
• Duodenal Ulcer: 40 mg once daily in the morning for 2 weeks; extend another 2 weeks if needed.
• Helicobacter pylori-associated Duodenal Ulcer: 40 mg twice daily along with Amoxicillin 1 g and Clarithromycin 500 mg, both twice daily for one week.
• NSAID-associated Gastric or Duodenal Ulcer Prophylaxis: 20 mg daily for long-term NSAID users.
• Zollinger-Ellison Syndrome: Start with 80 mg once daily; adjust based on response (maximum 40 mg daily in elderly); doses above 80 mg should be divided.

IV Injection:

• Duodenal and Gastric Ulcer: 40 mg once daily for 7-10 days.
• GERD with Erosive Esophagitis History: 40 mg once daily for 7-10 days.
• Peptic Ulcer Bleeding Prevention: IV 80 mg, then 8 mg/hour infusion for 72 hours.
• Acid Aspiration Prophylaxis: 80 mg IV every 12 hours for 24 hours, followed by 40 mg every 12 hours.
• Long-term Zollinger-Ellison Syndrome Management: 80 mg IV every 12 hours; may increase to 80 mg every 8 hours if needed.

Interaction

No significant drug interactions have been observed.

Contraindications

Trupan should not be used by individuals with a known hypersensitivity to its components.

Side Effects

Trupan is generally well-tolerated. Common side effects include headache and diarrhea. Rare side effects include abdominal pain, flatulence, rash, insomnia, and hyperglycemia.

Pregnancy & Lactation

Pantoprazole is classified as a Category B drug by the US FDA. While no well-controlled studies exist for pregnant women, it should be used during pregnancy only if necessary. Pantoprazole is excreted in breast milk, so a decision should be made to either discontinue nursing or the drug.

Precautions & Warnings

Patients should avoid splitting, chewing, or crushing Trupan tablets. Long-term use may lead to Vitamin B12 deficiency or increase the risk of osteoporosis-related disorders.

Overdose Effects

No specific overdose symptoms are known. Since Trupan is highly protein-bound, it is not easily dialyzable. Symptomatic and supportive treatment is recommended.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

IV Injection:

• Use 10 ml of 0.9% Sodium Chloride Injection to reconstitute the lyophilized powder. Administer as a slow intravenous injection over at least 2 to 5 minutes. The reconstituted solution can be stored at room temperature for up to 4 hours.

IV Infusion:

• Reconstitute with 10 ml of 0.9% Sodium Chloride Injection and further dilute to 100 ml with 0.9% Sodium Chloride Injection, 5% Dextrose, or Lactated Ringer’s Injection. The solution should be used within 24 hours after initial reconstitution.

Storage Conditions

Store in a dry place, away from light and heat. Keep out of reach of children.

Chemical Structure

• Molecular Formula: C16H15F2N3O4S
• Chemical Structure: Pantoprazole Sodium

Common Questions about Trupan 20 mg Tablet

What is Trupan 20 mg Tablet? Trupan 20 mg Tablet is a proton pump inhibitor used to treat conditions like peptic ulcers, GERD, NSAID-induced ulcers, Helicobacter pylori infections, and Zollinger-Ellison Syndrome.

How long should I use Trupan 20 mg Tablet before seeing improvement? You should continue taking Trupan until your condition improves, as advised by your doctor.

What is the recommended dosage frequency for Trupan 20 mg Tablet? Follow your doctor’s prescription for dosage frequency.

Should Trupan 20 mg Tablet be taken on an empty stomach, before, or after meals? Take Trupan 20 mg Tablet about 30 minutes before a meal.

How should Trupan 20 mg Tablet be stored and disposed of? Store Trupan in a cool, dry place in its original packaging. Ensure it is out of reach of children and pets.

What are the effects of Trupan 20 mg Tablet on older adults? Older adults may have an increased risk of bone fractures with prolonged use. Consult your doctor about ways to prevent bone loss.

How long does it take for Trupan 20 mg Tablet to work? You should start feeling better within 2 to 3 days, with full effects taking up to 4 weeks.

Is Trupan 20 mg Tablet safe? Trupan is generally safe when taken as prescribed. Consult your doctor before use.

Does Trupan 20 mg Tablet cause weight gain? Weight gain is a rare side effect. Consult your doctor if you have concerns.

What are the side effects of Trupan 20 mg Tablet? Possible side effects include headache, diarrhea, constipation, and allergic reactions.

Can I take Trupan 20 mg Tablet if I am pregnant or breastfeeding? Only use Trupan during pregnancy or breastfeeding if prescribed by your doctor.

What should I do if I miss a dose of Trupan 20 mg Tablet? If you miss a dose, take it as soon as you remember unless it’s close to the next dose. Do not double up doses.