Mirakof SR 50

Indications

Mirakof SR serves as a remedy for dry (non-productive) cough, commonly stemming from recent viral infections. It’s also beneficial for managing pre- and post-operative cough sedation in patients undergoing surgical procedures and bronchoscopy. Additionally, it addresses acute cough of various origins, including whooping cough and cough associated with acute lower respiratory tract infections like tracheitis, laryngitis, and bronchitis.

Pharmacology

Butamirate Citrate operates directly on the brain’s cough center to suppress cough reflex. Being safe and non-sedating, it lacks chemical or pharmacological relations to opium alkaloids. The rapid and complete absorption of Butamirate Citrate after oral administration leads to maximum concentration within 9 hours with sustained-release tablets. It’s highly protein-bound with a plasma elimination half-life of about 13 hours. The active metabolites of Butamirate Citrate also possess antitussive properties.

Dosage & Administration

For adults:

• Butamirate Citrate 50 mg tablet: 2-3 tablets daily.
• Butamirate Citrate syrup: 15 ml 4 times daily.

For children & adolescents:

• Butamirate Citrate 50 mg tablet:
  • Adolescent over 12 years old: 1-2 tablets daily.
• Butamirate Citrate syrup:
  • Children (3-6 yrs): 5 ml 3 times daily.
  • Children (6-12 yrs): 10 ml 3 times daily.
  • Adolescent: 15 ml 3 times daily.
• Butamirate Citrate pediatric drops:
  • Children (2 months-1 yr): 0.50 ml 4 times daily.
  • Children (1-3 yrs): 0.75 ml 4 times daily.

Interaction

Avoid concurrent use with expectorants.

Contraindications

Avoid in cases of hypersensitivity to the active ingredient.

Side Effects

Tolerance to Mirakof SR is generally good. Adverse reactions such as rash, nausea, diarrhea, and vertigo have been reported in rare cases, typically resolving with dose adjustment or discontinuation of treatment.

Pregnancy & Lactation

Avoid Butamirate Citrate during the first trimester of pregnancy. During later stages, use under medical guidance but with caution. Considering the lack of data on active substance elimination in breast milk, weigh the benefits against risks before administering Butamirate Citrate during breastfeeding.

Precautions & Warnings

Mirakof SR suppresses cough reflex; hence, avoid concomitant use with expectorants to prevent mucus retention and associated risks of bronchospasm and respiratory infections. Consult a doctor if cough persists beyond 7 days (3 days in children under 12 years).

Overdose Effects

Accidental overdose may lead to symptoms like drowsiness, nausea, vomiting, diarrhea, loss of balance, and hypotension. Follow standard emergency procedures, including activated charcoal, saline laxatives, and cardio-respiratory resuscitation.

Therapeutic Class

Cough suppressant

Storage Conditions

Store below 30°C, away from light and moisture. Keep all medicines out of children’s reach.