Zolium 0.5

Indications

Zolium is prescribed for:

• Anxiety disorders
• Short-term relief of anxiety
• Anxiety linked with depression
• Panic disorders, with or without agoraphobia

Always consult a registered healthcare professional before taking medication.

Pharmacology

Alprazolam, the active ingredient in Zolium, belongs to the 1,4-benzodiazepine class and acts as an anxiolytic, exhibiting hypnotic and anticonvulsant properties. It is believed to exert its effects by interacting with the Gamma Aminobutyric Acid (GABA)-benzodiazepine receptor complex. Like other benzodiazepines, its central nervous system (CNS) depressant activity varies by dosage, leading to effects ranging from mild impairment to complete sedation.

Dosage & Administration

Initiate treatment with 0.25 to 0.5 mg taken three times daily. Based on patient response, the dosage may be increased at intervals of 3 to 4 days, with a maximum increase of 1 mg/day. The total daily dose should not exceed 4 mg. In certain cases of panic disorder, dosages may reach up to 10 mg daily, necessitating regular reassessment and potential dosage adjustments.

Tailor the dosage to achieve the best therapeutic effect with the lowest effective dose. If side effects occur at the initial dosage, consider reducing the amount. When discontinuing treatment, gradually taper the dosage by no more than 0.5 mg every three days.

For elderly patients or those with advanced liver disease, begin with 0.25 mg, taken two to three times daily, with gradual increases as tolerated.

Patients switching from 0.25/0.5 mg formulations to 1 mg should take the latter once daily, ideally in the morning. Tablets should be swallowed whole and not chewed, crushed, or broken.

Always consult a registered healthcare professional before taking medication.

Interaction

The CNS depressant effects of Zolium may be intensified by concurrent use of other psychotropic medications, anticonvulsants, antihistamines, alcohol, and oral contraceptives.

Side Effects

Most side effects occur early in treatment and typically resolve with continued use. Common side effects include drowsiness and light-headedness, while others may include depression, headaches, confusion, dry mouth, and constipation.

Pregnancy & Lactation

Alprazolam falls under pregnancy category D, indicating it should be avoided during pregnancy. Additionally, like other benzodiazepines, Alprazolam may be excreted in breast milk; therefore, breastfeeding is not recommended for mothers using this medication.

Precautions & Warnings

Due to the potential for psychological and physical dependence, any dose adjustments or abrupt discontinuation of Zolium should only occur under medical supervision. The duration of therapy should be determined by a healthcare professional. Caution is advised for patients with liver or kidney issues, chronic respiratory conditions, or sleep apnea.

Use in Special Populations

The safety and efficacy of Zolium in individuals under 18 years have not been established.

Overdose Effects

Signs of Zolium overdose may include extreme drowsiness, confusion, impaired coordination, reduced reflexes, and coma. In cases of overdose, provide general supportive care along with immediate gastric lavage.

Therapeutic Class

Benzodiazepine sedatives

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.