Xynovir

Indications

• Xynovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults.
• It is also used for managing chronic hepatitis B in adult patients.

Use Xynovir as directed by a registered healthcare provider.

Pharmacology

• Mechanism of Action: Xynovir contains Tenofovir, which inhibits the activity of HIV reverse transcriptase by competing with deoxyadenosine 5-triphosphate. As an analog of naturally occurring deoxynucleotides, Tenofovir integrates into the viral DNA chain, preventing its synthesis.
• Pharmacokinetics: Tenofovir is a water-soluble prodrug with approximately 25% oral bioavailability. After administration, peak serum concentrations are typically reached in 1-2 hours. Tenofovir binds minimally to plasma proteins, and its half-life is about 17 hours. The drug is eliminated through a combination of glomerular filtration and active tubular secretion.

Dosage & Administration

• For HIV-1 or Chronic Hepatitis B Treatment:
  • Adults: Take 1 tablet of 245 mg Tenofovir once daily, orally, without regard to food.
  • Pediatric Patients (12 years or older, ≥35 kg): 1 tablet of 245 mg once daily, orally.
• Adjustments may be required for patients with renal impairments.

Consult your healthcare provider for personalized dosing instructions.

Interactions

• Didanosine: Caution is required when using Xynovir alongside Didanosine. Close monitoring for adverse reactions is recommended.
• Atazanavir: Patients taking Atazanavir and Xynovir together should be closely monitored for potential adverse effects.
• Lopinavir / Ritonavir: Co-administration with these drugs requires monitoring for any side effects related to Xynovir.

Contraindications

• Xynovir should not be used in patients with:
  • Severe kidney disease, liver disease, or bone density issues.
  • Pregnant women (use only if absolutely necessary) or breastfeeding mothers.

Side Effects

• Common side effects of Xynovir include:
  • Headache, diarrhea, nausea, and weakness.
  • Less common side effects: indigestion, chest pain, drowsiness, high cholesterol, kidney issues, or mental health concerns (depression, anxiety).

Consult your healthcare provider if you experience severe side effects.

Pregnancy & Lactation

• Pregnancy: Category B. Xynovir should be used during pregnancy only when the benefits outweigh potential risks to the fetus.
• Lactation: It is unknown if Xynovir is excreted in human milk. Avoid breastfeeding during treatment unless necessary.

Precautions & Warnings

• Lactic acidosis and severe hepatomegaly with steatosis have been reported in combination therapy with Xynovir.
• Patients discontinuing Xynovir may experience a worsening of hepatitis or renal impairments.
• Fat redistribution and immune reconstitution syndrome may also occur in patients undergoing HIV treatment.

Use in Special Populations

• Renal Impairment: Adjust Xynovir dosage for patients with renal impairment.
• Pediatric: Not recommended for children under 12 years of age.
• Geriatric: No significant differences noted, but caution is advised due to age-related organ function decline.

Therapeutic Class

• Anti-retroviral drugs for HIV treatment and hepatitis B management.

Storage Conditions

• Store Xynovir at temperatures between 20°C to 25°C, away from direct light.
• Keep out of reach of children.