Name: Vulcan 150
Brand: Beximco Pharmaceuticals Ltd
SKU: 19711
Price: 2000.00 BDT
Availability: InStock

Vulcan 150

2,000.00৳ Strip

Vulcan is an antifungal medication used to prevent recurrent vulvovaginal candidiasis (RVVC) in women who are not of reproductive potential.
It contains oteseconazole, which inhibits fungal growth by targeting sterol biosynthesis.
Vulcan is administered through two dosing regimens, either alone or in combination with fluconazole, and is taken orally with food.
It is contraindicated during pregnancy and lactation due to potential risks to the fetus and breastfeeding infant.

Brand

Beximco Pharmaceuticals Ltd

Generics

Oteseconazole

Type

Capsule

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Indication:

Vulcan is prescribed to reduce the recurrence of vulvovaginal candidiasis (RVVC) in women with a history of RVVC who are not of reproductive potential. Antifungal therapy should be adjusted based on fungal culture results.

Pharmacology:

Active Ingredient: Oteseconazole
Mechanism: Oteseconazole inhibits the 14α-demethylase enzyme, which is essential for fungal sterol biosynthesis. This disruption leads to toxic sterols accumulating in fungi, affecting cell membrane integrity. Oteseconazole has a low affinity for human enzymes.

Dosage & Administration:

Oteseconazole-Only Regimen:
- Day 1: 600 mg
- Day 2: 450 mg
- Days 14-24: 150 mg weekly for 11 weeks
Fluconazole/Oteseconazole Regimen:
- Days 1, 4, 7: 150 mg Fluconazole
- Days 14-20: 150 mg Oteseconazole daily
- Days 28-38: 150 mg Oteseconazole weekly for 11 weeks
Administration: Take with food; swallow capsules whole—do not chew, crush, or open.

Interactions:

BCRP Substrates: May increase the risk of adverse reactions. Consider dose adjustments and monitor closely.

Contraindications:

Females of reproductive potential
Pregnant and lactating women
Individuals with known hypersensitivity to oteseconazole

Side Effects:

Common reactions include headache and nausea.

Pregnancy & Lactation:

Pregnancy: Contraindicated due to potential fetal harm.
Lactation: Contraindicated; insufficient data on transfer to breast milk or effects on infants.

Precautions & Warnings:

Avoid use in reproductive-age women, during pregnancy, and lactation due to significant risks.
Monitor for potential fetal harm and ocular abnormalities observed in animal studies.

Special Populations:

Pediatric Use: Not recommended.
Geriatric Use: Limited data; no significant differences observed.
Renal Impairment: No dosage adjustment for mild to moderate impairment.
Hepatic Impairment: No adjustment needed for mild hepatic impairment.

Storage Conditions:

Store at 20°C to 25°C.
Protect from light.
Keep out of reach of children.