Indications
Vonokit and Vonocab Trio are recommended for eradicating H. pylori in cases of active chronic gastritis, duodenal, and gastric ulcers.
Composition
Vonokit contains Vonoprazan, Amoxicillin, and Clarithromycin. Each Vonocab Trio blister includes double the components of Vonokit.
Pharmacology
This triple therapy effectively targets H. pylori, combining Vonoprazan’s gastric acid suppression with Amoxicillin and Clarithromycin’s antibacterial properties.
Dosage & Administration
The regimen involves twice-daily doses of Vonoprazan, Amoxicillin, and Clarithromycin for 14 days, preferably with meals.
Interaction
Caution is advised when co-administering with drugs like tacrolimus, clopidogrel, and ritonavir due to potential interactions.
Contraindications
Avoid in patients with known hypersensitivity to any of the components, including Vonoprazan, Amoxicillin, or Clarithromycin.
Side Effects
Common adverse reactions may include dysgeusia, diarrhea, headache, and abdominal pain.
Pregnancy & Lactation
Use caution during pregnancy and lactation, especially with Clarithromycin, as data on Vonoprazan’s effects in human milk is lacking.
Precautions & Warnings
Monitor for severe hypersensitivity reactions, cutaneous adverse reactions, and Clostridioides difficile-associated diarrhea.
Overdose Effects
In case of overdose, immediate medical consultation is advised.
Therapeutic Class
These medications belong to the class of anti H. pylori drugs.
Storage Conditions
Store below 30°C, in a dry place, away from light, and out of children’s reach.
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