Voligel Max

Indications

• Rheumatology: Effective for inflammatory and degenerative rheumatism, including chronic polyarthritis, ankylosing spondylitis, osteoarthritis, and acute gout. Also addresses peri-articular rheumatic disorders.
• Surgery and Traumatology: Provides relief for sprains, bruises, dislocations, fractures, soft tissue injuries, and post-surgical recovery.
• Obstetrics and Gynecology: Treats primary dysmenorrhea, episiotomy recovery, adnexitis, endometritis, parametritis, salpingitis, and mastitis.
• Otorhinolaryngology: Used pre-operatively to manage pain, inflammation, and swelling.
• Dentistry: Reduces post-operative and post-traumatic pain, inflammation, and swelling.
• Other Uses: Manages pain and inflammation in urogenital tract surgeries and renal or biliary colic.

Pharmacology

Voligel Max contains Diclofenac Sodium, a powerful NSAID known for its anti-rheumatic, anti-inflammatory, analgesic, and antipyretic effects. It works by inhibiting prostaglandin synthesis, which reduces inflammation, pain, and fever. Diclofenac is rapidly absorbed, reaching peak plasma levels within 2 hours and is highly protein-bound. It undergoes first-pass metabolism in the liver.

Dosage & Administration

• Diclofenac FC Tablet: Adults: 75-150 mg daily in 2-3 doses after food. Reduce dose for long-term use.
• Diclofenac SR Tablet: Adults: 1 tablet daily with liquid at mealtimes; may increase to 150 mg. Children: 1-3 mg/kg body weight daily.
• Diclofenac Dispersible Tablet: Adults: 2-3 tablets daily, up to 150 mg. Children: Not generally recommended except for juvenile rheumatoid arthritis (1-3 mg/kg body weight). Dissolve in water before swallowing.
• Diclofenac TR Capsule: 1 capsule daily, preferably after meals.
• Diclofenac Suppository: Adults: 50 mg, 2-3 times daily, up to 150 mg.
• Diclofenac Injection: 1 ampoule daily, may increase to 2 in severe cases.
• Diclofenac Gel: Apply 2-4 g to affected areas 3-4 times daily. Rub in lightly; can be used alongside other Diclofenac forms.

Interaction

• Lithium & Digoxin: May increase plasma levels.
• Anticoagulants: Possible increased bleeding risk; monitor closely.
• Antidiabetic Agents: No significant interaction reported.
• Cyclosporin: Caution advised due to risk of nephrotoxicity.
• Methotrexate: Avoid concurrent use due to toxicity risk.
• Quinolone Antimicrobials: Potential for convulsions; use with caution.
• Other NSAIDs & Steroids: May increase side effects.

Contraindications

• Hypersensitivity to Diclofenac or any ingredients.
• Not suitable for individuals with a history of peptic ulcer, cutaneous epithelioma, or asthma exacerbated by NSAIDs.

Side Effects

• Mild, transient side effects such as epigastric pain, nausea, diarrhea, dizziness, or headache. Possible skin reactions include rash, eczema, and irritation from the gel.

Pregnancy & Lactation

• Use during pregnancy only if absolutely necessary; avoid during the first trimester. Diclofenac Sodium Gel is not recommended during pregnancy. Minimal Diclofenac may be present in breast milk, with no expected adverse effects on infants.

Precautions & Warnings

• Monitor for peptic ulceration or gastrointestinal bleeding. Avoid contact with eyes or mucous membranes; wash hands after application. Not to be ingested.

Therapeutic Class

• Drugs for Osteoarthritis, Rheumatoid Arthritis, NSAIDs

Storage Conditions

• Store in a cool, dry place, away from light, below 30°C. Keep out of reach of children.