Vibrenta Vial

Indications

Vibrenta is prescribed to help manage blood sugar levels in adults and children with type 1 diabetes mellitus and adults with type 2 diabetes mellitus.
Use as directed by a licensed healthcare provider.

Pharmacology

Vibrenta contains Insulin Glargine, a sterile, long-acting insulin analogue formulated for subcutaneous injection. It lowers blood glucose levels by enhancing glucose uptake in skeletal muscle and fat while suppressing glucose production in the liver. Insulin Glargine also inhibits the breakdown of fats and proteins while promoting protein synthesis. Manufactured through recombinant DNA technology, its glucose-lowering effect lasts up to 24 hours.

Dosage

Vibrenta (Insulin Glargine) provides consistent blood sugar control throughout the day, allowing for once-daily dosing. Its potency is similar to human insulin. The dosage should be tailored to the individual based on clinical response. Daily blood glucose monitoring is crucial, especially for patients with diabetes.

• For type 1 diabetes, Vibrenta should be combined with short-acting insulin.
• For type 2 diabetes, the starting dose for those not currently on insulin is 10 units (or 0.2 units/kg) once daily, adjusted as needed.

Switching to Vibrenta

• Transitioning from once-daily NPH insulin: Use the same dose of Vibrenta as the discontinued NPH dose.
• Transitioning from twice-daily NPH insulin: Start with 80% of the total NPH dose when switching to once-daily Vibrenta.
  Always consult your healthcare provider before making any changes to your insulin regimen.

Administration

Vibrenta should be injected subcutaneously at the same time every day.

Cartridge Usage

1. Properly load the cartridge into the pen and attach the needle.
2. Gently rotate the pen to mix the insulin.
3. Set the correct dosage, remove air bubbles, and inject as directed.
   Always ensure the needle remains sterile to avoid contamination.

Vial Usage

1. Wash your hands before use.
2. If it’s a new vial, remove the protective cap and clean the stopper with an alcohol swab.
3. Draw air into the syringe, inject it into the vial, and withdraw the correct dose of insulin.
4. Tap the syringe to remove any air bubbles before injecting.

Injection Sites

Use less tense skin areas like the upper arms, thighs, abdomen, or buttocks. Rotate injection sites to avoid tissue damage, maintaining at least 1 cm distance from the previous injection site.

Injection Method

Clean the skin with alcohol, inject at a 45° angle, and apply gentle pressure to the site post-injection without rubbing.

Drug Interactions

Various medications can affect blood sugar control, requiring dose adjustments:

• Lower blood sugar: Oral anti-diabetic drugs, ACE inhibitors, fibrates, and fluoxetine.
• Increase blood sugar: Thiazides, glucocorticoids, thyroid hormones, and beta-sympathomimetics.
  Beta-blockers, clonidine, lithium, and alcohol may affect insulin’s blood sugar-lowering effects.

Contraindications

Vibrenta should not be used by individuals allergic to Insulin Glargine or any of its components.

Side Effects

Possible side effects include hypoglycemia, allergic reactions, injection site irritation, lipodystrophy, itching, and rashes.

Pregnancy & Lactation

Classified as pregnancy category C, Vibrenta should only be used during pregnancy if the potential benefit outweighs the risk to the fetus. It’s unknown if insulin glargine is excreted in human milk, so caution is advised for breastfeeding mothers.

Precautions & Warnings

• Regular blood sugar monitoring is necessary.
• Do not mix or dilute Vibrenta with other insulin or solutions.
• Avoid intravenous administration, as it may lead to severe hypoglycemia.
• Use with caution in individuals with kidney or liver impairment, as dose adjustments may be needed.

Over dose Management

An overdose of Vibrenta may lead to hypoglycemia. Mild cases can be managed with oral carbohydrates, while severe cases may require intravenous glucose or glucagon injections. Adjustments in diet, medication, or physical activity may be necessary.

Therapeutic Class

Long-Acting Insulin

Storage Instructions

Keep Vibrenta refrigerated at 2°C to 8°C. Do not freeze and protect from light.