Vertina-D

Indications

For the treatment of nausea and vomiting during pregnancy in women unresponsive to conservative management.

Pharmacology

Doxylamine Succinate functions as an antihistamine by blocking Histamine (H1) receptors. Its ability to penetrate the blood-brain barrier allows it to effectively block H1 receptors in the brain, thereby reducing histamine action. Additionally, it inhibits the vestibular system and Muscarinic receptors, contributing to its antiemetic effects. Pyridoxine Hydrochloride, a vitamin B6 analog, complements this action with its own antiemetic properties.

Dosage & Administration

Begin with one tablet orally at bedtime on Day 1. If symptoms are adequately controlled the following day, maintain a daily bedtime dose. If symptoms persist on Day 2, increase dosage to one tablet in the morning and one at bedtime. The maximum recommended daily dose is two tablets, one in the morning and one at bedtime. Administer on an empty stomach with water, swallowing tablets whole. Avoid crushing, chewing, or splitting tablets. Take daily as prescribed, not on an as-needed basis.

Interactions

Avoid concomitant use with monoamine oxidase inhibitors (MAOIs) due to potentiation of central nervous system effects. Concurrent use with alcohol and other CNS depressants is not advised.

Contraindications

Do not use in individuals with known hypersensitivity to Doxylamine Succinate, Pyridoxine Hydrochloride, or any inactive ingredient. Avoid use with MAO inhibitors.

Side Effects

May cause somnolence or accidents when combined with CNS depressants.

Pregnancy & Lactation

Pregnancy category A. Use caution during breastfeeding due to excretion of both compounds in breast milk.

Precautions & Warnings

Exercise caution in activities requiring alertness due to potential somnolence. Avoid use with CNS depressants, including alcohol. Use with caution in individuals with asthma, increased intraocular pressure, narrow angle glaucoma, peptic ulcer, pyloroduodenal obstruction, or urinary bladder-neck obstruction.

Overdose Effects

Signs and symptoms may not be immediately apparent due to extended-release formulation. Symptoms may include restlessness, dry mouth, dilated pupils, drowsiness, vertigo, confusion, and tachycardia. Severe overdose can lead to seizures, rhabdomyolysis, renal failure, and death. Treatment may involve gastric lavage, activated charcoal, whole bowel irrigation, and symptomatic management.

Therapeutic Class

Anti-emetic medications.

Storage Conditions

Store below 30°C in a dry, light-protected area. Keep out of reach of children.