Name: Valoate CR 500
Brand: Square Pharmaceuticals PLC
SKU: 18397
Price: 120.30 BDT
Availability: InStock

Valoate CR 500

120.30৳ Strip

Valoate CR Vaiproate is indicated for:
- Various types of epilepsy including partial, absence, and generalized seizures
- Prophylaxis of febrile convulsions and post-traumatic epilepsy
- Treatment of bipolar disorder
- Prophylaxis against migraines
Available formulations:
- Enteric-coated tablets (200 mg)
- Syrup (200 mg/5 ml)
- Controlled-release tablets (200 mg, 300 mg, 500 mg)
- Injectable solution (500 mg/5 ml)
Mechanism of action involves potentially increasing brain levels of gamma-aminobutyric acid (GABA).
Important considerations:
- Contraindicated in patients with hypersensitivity to the drug or liver dysfunction
- Restricted use during pregnancy and in women of childbearing potential
- Monitor for common side effects such as anorexia, nausea, and CNS effects like sedation and tremor

Brand

Square Pharmaceuticals PLC

Generics

Sodium Valproate

Type

Tablet

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Indications

Valoate CR Vaiproate is indicated for the treatment of various medical conditions:

All types of epilepsy: Partial seizures, absence seizures (petit mal), generalized tonic-clonic seizures (grand mal), myoclonic seizures, atonic seizures, and mixed seizures including absence attacks.
Prophylaxis of febrile convulsions and post-traumatic epilepsy.
Treatment of bipolar disorder and prophylaxis of migraine.

Composition

Formulations include:

Sodium Valproate tablets: Each enteric-coated tablet contains 200 mg Sodium Valproate BP.
Sodium Valproate syrup: Each 5 ml syrup contains 200 mg Sodium Valproate BP.
Sodium Valproate controlled release tablets: Available in 200 mg, 300 mg, and 500 mg strengths, designed for sustained release.
Sodium Valproate injection: Each 5 ml injectable solution contains Sodium Valproate BP equivalent to 500 mg Valproic Acid.

Pharmacology

Sodium Valproate potentially increases brain levels of gamma-aminobutyric acid (GABA), though its precise mechanism remains unclear.

Dosage & Administration

Administration:

Oral tablets and syrup are administered in divided doses based on patient requirements.
Injection formulations are administered cautiously according to body weight and medical condition.

Interaction

Valoate CR Vaiproate may interact with drugs like Phenobarbital, Phenytoin, Warfarin, and Aspirin, impacting their metabolism.

Contraindications

Avoid Sodium Valproate in cases of known hypersensitivity to the drug or liver dysfunction. Use is restricted during pregnancy and in women of childbearing potential.

Side Effects

Common side effects include anorexia, nausea, and vomiting. CNS effects such as sedation and tremor may occur infrequently but can be managed with dose adjustments.

Pregnancy & Lactation

Use with caution during pregnancy due to potential fetal risks and consider alternatives while breastfeeding.

Precautions & Warnings

Monitor liver function before and during therapy, particularly in high-risk patients. Exercise caution in renal impairment and systemic lupus erythematosus.

Therapeutic Class

Primary anti-epileptic drugs.

Storage Conditions

Store below 30°C, shield from light, and keep out of reach of children.