Valoate 100ml

Indications

Sodium Valproate oral is prescribed for the treatment of various forms of epilepsy, including:

• Partial seizures
• Absence seizures (petit mal)
• Generalized tonic-clonic seizures (grand mal)
• Myoclonic seizures
• Atonic seizures
• Mixed seizures incorporating absence attacks
• Prophylaxis of febrile convulsions
• Prophylaxis of post-traumatic epilepsy

It is also effective in managing bipolar disorder and preventing migraines.

Composition

• Sodium Valproate tablet: Each enteric-coated tablet contains 200 mg of Sodium Valproate BP.
• Sodium Valproate syrup: Each 5 ml of syrup contains 200 mg of Sodium Valproate BP.
• Sodium Valproate controlled release tablets: Available in strengths of 200 mg, 300 mg, and 500 mg, designed for sustained release to maintain therapeutic levels.
• Sodium Valproate injection: Each 5 ml injectable solution contains Sodium Valproate BP equivalent to 500 mg of Valproic Acid.

Pharmacology

Sodium Valproate exerts its anti-epileptic effects by potentially increasing brain levels of gamma-aminobutyric acid (GABA), although the exact mechanism is not fully understood.

Dosage & Administration

Oral administration is typically recommended for Sodium Valproate tablets and syrup. Dosage varies based on the condition being treated:

• For epilepsy in adults, initial doses start at 600 mg daily, increasing gradually.
• Pediatric doses are adjusted by weight and age.
• For bipolar disorder and migraine prophylaxis, specific dosing guidelines apply.

Interaction

Sodium Valproate may inhibit the metabolism of other drugs, notably Phenobarbital, Phenytoin, Warfarin, and Aspirin, leading to potential interactions.

Contraindications

Avoid Sodium Valproate in patients with known hypersensitivity, liver dysfunction, or during pregnancy and in women of childbearing potential.

Side Effects

Common side effects include gastrointestinal disturbances, CNS effects like sedation and tremors, and occasionally rash or alopecia. Regular monitoring can mitigate adverse hepatic effects.

Pregnancy & Lactation

Use caution during pregnancy due to the risk of neural tube defects. Breastfeeding while taking Sodium Valproate is generally considered safe under medical supervision.

Precautions & Warnings

Routine liver function tests are advisable during initial therapy. Avoid abrupt discontinuation. Careful monitoring is crucial in patients with renal impairment or systemic lupus erythematosus.

Therapeutic Class

Sodium Valproate belongs to the primary class of anti-epileptic drugs.

Storage Conditions

Store below 30°C, protect from light, and keep out of reach of children.