Urocure 100 SR

Indications

Urocure SR is specifically indicated for the treatment & prophylaxis of urinary tract infections caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.

Pharmacology

Nitrofurantoin is an antibacterial agent specific for urinary tract infections. Nitrofurantoin inactivates or alters bacterial ribosomal proteins and other macromolecules. Nitrofurantoin has been shown to be active against various bacteria, including Gram-positive Aerobes and Gram-Negative Aerobes.

Dosage

• Nitrofurantoin tablet (In adults): Uncomplicated urinary tract infections: 50-100 mg four times a day. For long-term suppressive therapy: 50-100 mg at bedtime.
• Nitrofurantoin capsule (In adults): Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for 7 days. For long term suppression: 50-100 mg once a day.
• Nitrofurantoin SR capsule: Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days.
• Nitrofurantoin suspension: Children: 5-7 mg/kg/day in four divided doses.

Administration

Nitrofurantoin should be taken with food.

Interaction

Antacids containing Magnesium Trisilicate may reduce the absorption of Urocure SR.

Contraindications

Anuria, oliguria or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Nitrofurantoin is also contraindicated in those patients with known hypersensitivity to Nitrofurantoin.

Side Effects

The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness and drowsiness.

Pregnancy & Lactation

Nitrofurantoin is Pregnancy Category B. Nitrofurantoin has been detected in human breast milk in trace amounts.

Precautions & Warnings

If acute, sub-acute or chronic pulmonary reactions occur, Urocure SR should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Urocure SR.

Overdose Effects

Occasional incidents of acute overdosage of Urocure SR have not resulted in any specific symptoms other than vomiting.

Therapeutic Class

Systemic Urinary Anti- infective

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.