Tuspel

Indications

Tuspel is formulated to address:

• Chest congestion
• Persistent cough
• Sore throat

Composition

Each 5 ml dose of syrup contains:

• Guaifenesin BP 200 mg
• Dextromethorphan Hydrobromide BP 15 mg
• Menthol USP 15 mg

Pharmacology

• Guaifenesin acts as an expectorant, loosening chest and throat congestion for easier expulsion.
• Dextromethorphan Hydrobromide functions as a cough suppressant, modulating the brain signals that trigger coughing.
• Menthol provides relief with its local anesthetic and counterirritant properties, soothing throat irritation.

Dosage & Administration

• Adults (12 years and older): 2 teaspoonfuls (10 ml) every 6 hours. Maximum: 8 teaspoonfuls (40 ml) per day.
• Pediatric Use: Not recommended for children under 12 years.

Interactions

Possible interactions may occur with acetaminophen, hydrocodone, diphenhydramine, escitalopram, codeine, alprazolam, and ondansetron.

Contraindications

Avoid use if currently taking monoamine oxidase inhibitors (MAOIs) or within two weeks of stopping MAOIs. Consult a healthcare provider if unsure about MAOI content in your medication.

Side Effects

Possible side effects include dizziness, drowsiness, gastrointestinal disturbances, and feelings of nervousness, restlessness, or irritability.

Pregnancy & Lactation

• Pregnancy: Category C. Use only if the benefits outweigh risks, as data on this combination during pregnancy is limited.
• Lactation: No data on excretion into breast milk; weigh the benefits against potential risks. Risk of Menthol during pregnancy is undetermined.

Precautions & Warnings

Consult a healthcare professional before use if you have asthma, chronic lung conditions, persistent cough, or are taking medications for depression, including MAO inhibitors.

Overdose Effects

• Guaifenesin: Low toxicity; treatment should focus on reducing absorption and gastric emptying.
• Dextromethorphan Hydrobromide: High doses may cause excitement, confusion, or respiratory depression. Cases of toxic psychosis have been reported.
• Menthol: Overdose can cause abdominal pain, diarrhea, nausea, vomiting, dizziness, and rapid breathing.

Therapeutic Class

Combined cough expectorants and suppressants.

Storage Conditions

Store below 30°C in a cool, dry place, protected from light. Keep out of reach of children.