Turboclav 500

Indications

Turboclav is prescribed for treating infections caused by susceptible bacteria, including:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media: Caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis: Caused by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase producing strains).
• Lower Respiratory Tract Infections, including Pneumonia: Caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus pyogenes, E. coli.
• Acute Bacterial Exacerbation of Chronic Bronchitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
• Uncomplicated Skin and Skin-Structure Infections: Caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes.
• Uncomplicated Urinary Tract Infections: Caused by E. coli or Klebsiella pneumoniae.
• Bone and Joint Infections: Caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains).
• Uncomplicated Gonorrhoea: Caused by both penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae.
• Early Lyme Disease (Erythema Migrans): Caused by Borrelia burgdorferi.
• Septicemia: Caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp..
• Meningitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (penicillinase and non-penicillinase producing strains).
• Switch Therapy: From injectable to oral.

Pharmacology

Turboclav combines Cefuroxime, a second-generation cephalosporin antibiotic, with Clavulanic Acid. Cefuroxime targets and kills a broad range of Gram-positive and Gram-negative bacteria by inhibiting cell wall synthesis. Clavulanic Acid, a beta-lactamase inhibitor, protects Cefuroxime from bacterial enzyme degradation, enhancing its efficacy against beta-lactam resistant bacteria.

Dosage & Administration

• Adolescents and Adults (13 years and older):
  • Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
  • Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
  • Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
  • Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
  • Uncomplicated Skin and Skin Structure Infections: 250-500 mg twice daily for 10 days.
  • Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
  • Uncomplicated Gonorrhoea: 1000 mg twice daily as a single dose.
  • Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
  • MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
  • Early Lyme Disease: 500 mg twice daily for 20 days.
• Pediatric Patients (3 months to 12 years):
  • Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days.
  • Acute Otitis Media: 30 mg/kg/day twice daily for 10 days.
  • Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day twice daily for 10 days.
  • Impetigo: 30 mg/kg/day twice daily for 10 days.

Cefuroxime-Clavulanic Acid tablets can be taken with or without food.

Interaction

The concomitant use of probenecid with Cefuroxime-Clavulanic Acid may increase the serum concentration levels by 50%. Drugs that reduce stomach acidity might lower the bioavailability of Cefuroxime, affecting absorption.

Contraindications

Cefuroxime-Clavulanic Acid is contraindicated in individuals with known allergy to cephalosporins or those with pseudomembranous colitis.

Side Effects

Cefuroxime-Clavulanic Acid is generally well tolerated. Possible side effects include nausea, vomiting, diarrhea, abdominal discomfort, and constipation. Rare side effects may involve renal dysfunction, anaphylaxis, angioedema, rash, and serum sickness-like urticaria.

Pregnancy & Lactation

This medication should be avoided in the first trimester if possible. However, it can be safely used during later pregnancy and lactation for treating infections, though potential infant sensitization should be considered.

Precautions & Warnings

Cefuroxime should be administered with caution to patients receiving potent diuretics and those with a history of colitis.

Therapeutic Class

Second-generation Cephalosporins.

Storage Conditions

Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.