Tezolin 200
1,000.00৳ Strip
- Tezolin is an oxazolidinone-class antibiotic for treating acute bacterial skin and skin structure infections (ABSSSI) in adults.
- The active ingredient, tedizolid, inhibits bacterial protein synthesis, targeting Gram-positive bacteria.
- It can be administered intravenously or orally for 6 days, with no dose adjustment needed when switching between methods.
- Use as prescribed and monitor for potential interactions and side effects.
Brand
|
Beximco Pharmaceuticals Ltd |
|---|---|
Generics
|
Tedizolid Phosphate |
Type
|
Tablet |
Indications
Tezolin is an antibiotic in the oxazolidinone class, used in adults to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible bacteria. To prevent the emergence of drug-resistant bacteria and maintain the effectiveness of Tezolin, it should only be prescribed for infections confirmed or strongly suspected to be caused by these specific bacteria.
Pharmacology
Tezolin’s active ingredient, tedizolid, becomes active after conversion by phosphatases. It functions by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit of Gram-positive bacteria. Tedizolid’s unique action reduces the likelihood of cross-resistance seen with other non-oxazolidinone antibiotics.
Dosage & Administration
- For Acute Bacterial Skin and Skin Structure Infections (ABSSSI):
- Intravenous: 200 mg once daily for 6 days (Infusion Time: 1 hour)
- Oral: 200 mg once daily for 6 days
Transitioning from intravenous to oral Tezolin requires no dose adjustment. If a dose is missed, it should be taken as soon as possible within 8 hours before the next scheduled dose. If less than 8 hours remain, skip the missed dose and continue with the next scheduled dose.
Always adhere to your healthcare provider’s instructions.
Interaction
Oral Tezolin can elevate plasma levels of Breast Cancer Resistance Protein (BCRP) substrates. Monitor patients for adverse reactions when coadministering with BCRP substrates if coadministration cannot be avoided.
Contraindications
No specific contraindications are known.
Side Effects
Common side effects (occurring in more than 2% of patients) include nausea, headache, diarrhea, vomiting, and dizziness.
Pregnancy & Lactation
- Pregnancy: Category C. Use Tezolin during pregnancy only if the benefits justify the potential risks to the fetus, as there are no well-controlled studies in pregnant women.
- Lactation: Tedizolid has been detected in rat breast milk. It is not known if it is excreted in human milk, so caution is recommended when administering to nursing mothers.
Precautions & Warnings
- Neutropenia: The safety and efficacy of Tezolin in patients with neutropenia (neutrophil counts <1000 cells/mm³) have not been fully evaluated. Alternative treatments should be considered for these patients.
- Clostridium difficile-associated Diarrhea: Monitor for and evaluate any occurrence of diarrhea.
Use in Special Populations
- Pediatric Use: The safety and efficacy of Tezolin in children under 18 have not been established.
- Geriatric Use: No significant pharmacokinetic differences were observed between elderly and younger patients, although clinical studies did not include a sufficient number of elderly participants.
Overdose Effects
In the event of an overdose, discontinue Tezolin and provide supportive care. Hemodialysis does not effectively remove tedizolid from systemic circulation.
Therapeutic Class
Antibiotic (Other)
Storage Conditions
Store tablets and injections at 20°C to 25°C.
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