Telmidip 40/5

Indications:

Telmidip is indicated for the effective management of hypertension either alone or in combination with other antihypertensive medications. It is particularly beneficial as an initial treatment for patients who may require multiple medications to meet their blood pressure goals.

Always follow the advice of a registered healthcare provider.

Pharmacology:

Telmidip is a fixed-dose combination of Telmisartan and Amlodipine, designed to target high blood pressure efficiently.

• Telmisartan: An angiotensin II receptor blocker (ARB), Telmisartan works by blocking the AT1 receptor, reducing vasoconstriction, aldosterone secretion, and sodium reabsorption, which all contribute to lowering blood pressure.
• Amlodipine: A calcium channel blocker (CCB), Amlodipine dilates blood vessels by inhibiting the influx of calcium ions into smooth muscle, thus reducing peripheral vascular resistance and blood pressure.

Dosage & Administration:

• Initial therapy: Begin with 40/5 mg once daily for patients who are unlikely to achieve blood pressure control with a single agent. The dose may be adjusted to 80/5 mg if greater blood pressure reduction is needed.
• Add-on therapy: For patients not adequately controlled with amlodipine or Telmisartan alone, this combination therapy can be introduced.
• Replacement therapy: Patients previously taking separate Telmisartan and Amlodipine tablets can switch to this combination therapy with the same dosage. Maximum recommended dose: 80/10 mg once daily.

Always take medication under the guidance of a registered physician.

Interactions:

• Telmisartan does not interact significantly with acetaminophen, amlodipine, or other commonly used medications. However, be cautious with certain drugs like ACE inhibitors or aldosterone blockers.
• Amlodipine is generally safe to use with a wide range of other medications including beta-blockers, diuretics, and antihypertensive drugs.

Contraindications:

• Hypersensitivity to any component.
• Pregnancy, lactation, and certain liver disorders.
• Avoid use in severe hypotension, cardiogenic shock, or obstructive coronary artery disease.

Side Effects:

• Common side effects include dizziness, peripheral edema, headache, and fatigue. Serious side effects may include hypotension, myocardial infarction, or severe allergic reactions.

Pregnancy & Lactation:

• Category C (first trimester), Category D (second and third trimester). Use only if the benefits outweigh the risks.
• It is unknown whether Telmisartan and Amlodipine pass into breast milk. Discontinue breastfeeding or the drug as necessary.

Precautions:

• Avoid fetal or neonatal exposure.
• Monitor closely for hypotension and renal function, especially in patients with liver or kidney issues.
• Heart failure patients should be carefully observed for worsening symptoms.

Overdose Effects:

• Telmisartan overdose may cause hypotension or tachycardia, while Amlodipine overdose may lead to excessive peripheral vasodilation and hypotension. Supportive treatment is recommended in case of overdose.

Therapeutic Class:

• Combination of Antihypertensive agents: A combination of ARB (Telmisartan) and CCB (Amlodipine) for effective blood pressure control.

Storage:

• Store below 30°C in a cool, dry place, away from light. Keep out of reach of children.