Silosin 8

Indications

Silosin, a selective alpha-1 adrenergic receptor blocker, is primarily used for managing the symptoms of benign prostatic hyperplasia (BPH). It is important to note that Silosin is not intended for treating hypertension.

• Effective Treatment for BPH: Silosin provides a reliable solution for alleviating the symptoms of benign prostatic hyperplasia.
• Uroselective Action: It is highly selective for the alpha-1 adrenergic receptors in the prostate and bladder.
• Alternative for Tamsulosin Non-Responders: Silosin is a suitable alternative for patients who do not respond to Tamsulosin.
• No Orthostatic Hypotension: Unlike some other treatments, Silosin does not cause orthostatic hypotension.
• Convenient Once-Daily Dosing: A single daily dose is sufficient for most patients.

Always use Silosin under the guidance of a registered healthcare provider.

Pharmacology

Silodosin is a selective antagonist targeting alpha-1 adrenergic receptors, found in key areas such as the prostate, bladder neck, and prostatic urethra. By blocking these receptors, Silodosin helps relax smooth muscle, enhancing urine flow and alleviating the symptoms of BPH.

Dosage & Administration

For optimal effectiveness, the recommended dosage of Silodosin is 8 mg once daily with food. For patients with moderate renal impairment (CrCl 30-50 mL/min), the dosage should be reduced to 4 mg daily, also taken with a meal.

Always follow your healthcare provider’s advice regarding medication use.

Drug Interactions

• P-glycoprotein Inhibitors (e.g., cyclosporine): Co-administration may elevate Silosin plasma concentrations.
• PDE5 Inhibitors (e.g., sildenafil): Concurrent use with Silosin may result in symptomatic hypotension.

Contraindications

Silodosin is contraindicated in patients with:

• Severe renal or hepatic impairment
• Use alongside strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
• Known hypersensitivity to Silodosin

Side Effects

Common side effects include:

• Retrograde ejaculation
• Dizziness
• Diarrhea
• Orthostatic hypotension
• Headache
• Nasal congestion
• Nasopharyngitis

Pregnancy & Lactation

• Pregnancy Category B: Silosin is not recommended for use in women. Studies in pregnant rabbits and rats showed no significant teratogenic effects, although slight maternal weight loss was observed at high doses. The safety of Silosin during pregnancy has not been established.
• Lactation: There is no information available on Silosin’s excretion in breast milk. It is not recommended for use by lactating women.

Precautions & Warnings

• Postural Hypotension: Be aware of the risk of postural hypotension, especially at the start of treatment.
• Combination with Other Alpha-Blockers: Silosin should not be used with other alpha-1 blockers.
• Cataract Surgery: If planning cataract surgery, inform your ophthalmologist as Silosin may increase the risk of Intraoperative Floppy Iris Syndrome (IFIS).

Use in Special Populations

• Pediatric Use: Silosin is not recommended for children.
• Geriatric Use: While Silosin has been used in patients aged 65 and older, no significant differences in safety or efficacy were found compared to younger patients. However, elderly patients are more likely to experience orthostatic hypotension.
• Renal Impairment: Patients with severe renal impairment should not use Silosin. For those with moderate renal impairment (CrCl 30-50 mL/min), the dosage should be reduced.
• Hepatic Impairment: Silosin should be avoided in patients with severe hepatic impairment, but no adjustment is needed for mild to moderate cases.

Overdose Effects

Excessive doses of Silosin may lead to postural hypotension. In case of overdose:

• Management: Place the patient in a supine position to restore blood pressure. Intravenous fluids and vasopressors may be required in severe cases.
• Dialysis: Due to Silosin’s high protein binding (97%), dialysis is unlikely to be effective.

Therapeutic Class

• BPH Treatment
• Urinary Retention & Incontinence

Storage Conditions

Store Silosin in a cool, dry place at temperatures below 30°C. Keep out of reach of children.