Seroxyn HFA 25/50

Indications

Seroxyn is used for the regular treatment of asthma in the following cases:

• Patients who are not adequately controlled with inhaled corticosteroids and “as needed” short-acting beta-2 agonists.
• Patients who are already adequately controlled on both inhaled corticosteroids and long-acting beta-2 agonists.

Pharmacology

• Salmeterol Xinafoate is a long-acting beta-2 agonist (12-hour duration) that helps in treating asthma by reducing bronchospasm.
• Fluticasone Propionate is a corticosteroid that works within the lungs to reduce inflammation and prevent asthma exacerbations.

Dosage

Inhaler Dosage:

• Adults and adolescents (12 years and older): Two puffs of either 25 µg salmeterol and 50 µg fluticasone, 125 µg, or 250 µg twice daily.
• Children (4-12 years): Two puffs of 25 µg salmeterol and 50 µg fluticasone twice daily.

Inhalation Capsule (Asthma):

• Adults and Adolescents (12 years and older): Salmeterol 50 µg & Fluticasone 100 µg or 250 µg twice daily.
• Children (4-11 years): Salmeterol 50 µg & Fluticasone 100 µg twice daily.

Maxhaler (For Asthma):

• Adults and Adolescents (12 years and older): 50/100, 50/250, or 50/500 inhaler once or twice daily depending on severity.

Maxhaler (For COPD):

• Adults and Adolescents (12 years and older): One inhalation twice daily.

Administration

• Shake the inhaler well before each use.
• Exhale fully before inhaling the medication.
• Hold the inhaler upright, place the mouthpiece between your teeth, and inhale slowly while pressing the inhaler to release the dose.
• Hold your breath for 10 seconds after inhaling.
• Rinse your mouth after each use to reduce side effects like thrush.

Interactions

• Avoid using non-selective beta-blockers in asthma patients, unless absolutely necessary.
• Be cautious when using strong CYP3A4 inhibitors (e.g., ketoconazole) as they may increase Fluticasone Propionate levels.

Contraindications

• Hypersensitivity to Salmeterol or Fluticasone or any excipients.
• Not recommended for acute asthma attacks.

Side Effects

• Salmeterol: Tremors, headaches, palpitations, arrhythmias, and muscle cramps.
• Fluticasone: Hoarseness, candidiasis (thrush), cutaneous hypersensitivity, and rare facial or oropharyngeal edema.

Pregnancy and Lactation

• Pregnancy: Use only if the benefits outweigh the risks.
• Lactation: Use with caution, as the amounts in breast milk are likely low.

Precautions and Warnings

• Asthma-related adverse events: Seek medical advice if asthma symptoms worsen.
• Paradoxical Bronchospasm: Can occur with inhalation therapy; treat immediately with a fast-acting bronchodilator.
• COPD patients: Watch for pneumonia, as it may occur more frequently in these patients.

Overdose Effects

• Salmeterol Overdose: Symptoms include seizures, tachycardia, arrhythmias, nervousness, and insomnia.
• Fluticasone Overdose: May cause temporary adrenal suppression.