Indications
Sedno serves as a remedy for symptoms linked with both seasonal and perennial allergic rhinitis, addressing issues like sneezing, nasal discharge, itching, congestion, ocular discomfort such as itching, tearing, redness, itching of the palate, and coughing. It is also effective in managing symptoms related to chronic idiopathic urticaria, including itching and the reduction in size and number of hives.
Pharmacology
Desloratadine, the primary active metabolite of Loratadine, acts as a non-sedating, long-acting tricyclic histamine antagonist, selectively targeting H1-receptor histamine antagonism. Additionally, Desloratadine hampers histamine release from human mast cells.
Dosage & Administration
For Pediatric drops:
- Children aged 6-11 months: 2 ml drops once daily.
- Children aged 1-2 years: 2.5 ml drops once daily.
For Syrup:
- Children aged 6-11 months: 2 ml once daily.
- Children aged 1-5 years: 2.5 ml once daily.
- Children aged 6-11 years: 5 ml once daily.
- Adults and those over 12 years: 10 ml once daily.
For Tablets:
- Adults and children aged 12 years and above: 1 tablet daily.
Consume medication as per physician’s advice.
Interaction
No significant drug interactions have been documented.
Contraindications
Desloratadine should not be administered to patients exhibiting hypersensitivity to the medication, its components, or Loratadine.
Side Effects
Potential side effects, albeit uncommon, may include headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia, and myalgia.
Pregnancy & Lactation
Designated as Pregnancy Category C, the safety of Desloratadine during pregnancy remains undetermined. Hence, its use during pregnancy is to be avoided unless absolutely necessary. Desloratadine can pass into breast milk, prompting a decision-making process regarding nursing continuation or discontinuation, considering the medication’s significance to the mother.
Precautions & Warnings
For adult patients with liver or renal impairment, commencing with one 5 mg tablet every other day is advised, guided by pharmacokinetic data. Special attention is warranted if the patient has a medical or familial history of seizures.
Use in Special Populations
Recommended for use in children and adolescents.
Overdose Effects
No clinically significant adverse effects have been recorded.
Therapeutic Class
Categorized as non-sedating antihistamines.
Storage Conditions
Store Sedno in a cool, dry place, shielded from light, and maintain it below 30°C. Ensure all medications are kept out of children’s reach.
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