Secrin M 1/500 XR
36.00৳ Strip
- This oral hypoglycemic preparation combines glimepiride and metformin.
- It supports the management of type 2 diabetes mellitus.
- The tablet serves as a complementary treatment alongside diet and exercise.
- It is particularly beneficial when monotherapy with glimepiride or metformin is inadequate.
- Glimepiride stimulates insulin release, while metformin improves insulin sensitivity and reduces hepatic glucose production.
- Careful dosage adjustments and regular monitoring are essential for optimal glycemic control and minimizing side effects.
Brand
|
Square Pharmaceuticals PLC |
|---|---|
Generics
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Glimepiride + Metformin |
Indications
This tablet serves as a complementary treatment alongside diet and exercise for patients with type 2 diabetes mellitus. It’s particularly beneficial when monotherapy with glimepiride or metformin fails to adequately control blood glucose levels or when replacing a combination therapy of glimepiride and metformin.
Pharmacology
Glimepiride, a sulfonylurea antidiabetic agent, lowers blood glucose levels by stimulating insulin release from pancreatic beta cells and enhancing beta cell sensitivity to glucose. Additionally, it reduces hepatic glucose production and improves peripheral tissue sensitivity to insulin. Metformin, a biguanide type oral antihyperglycemic drug, works by lowering basal and postprandial plasma glucose levels through various mechanisms, including decreased hepatic glucose production and increased peripheral glucose uptake and utilization.
Dosage
The dosage of this tablet should be adjusted to achieve the desired blood glucose level while minimizing side effects. Regular monitoring of blood glucose levels is essential during treatment, and any deviations should be promptly addressed. Dose adjustments may be necessary over time to maintain optimal control of diabetes and prevent hypoglycemia.
Administration
This tablet should be swallowed whole and not crushed or chewed to ensure proper absorption and effectiveness.
Interaction
Several factors can influence the effectiveness of this tablet, including coadministration with other medications. It’s important to consider potential interactions with drugs that affect glucose metabolism and adjust dosage accordingly.
Contraindications
This tablet is contraindicated in certain populations, including individuals with hypersensitivity to its components, pregnant or breastfeeding women, and those with severe impairment of liver or renal function.
Side Effects
Common side effects of this tablet may include gastrointestinal symptoms such as nausea and abdominal pain, while more serious adverse reactions like hypoglycemia and hepatic dysfunction are possible but rare.
Pregnancy & Lactation
The use of this tablet during pregnancy and lactation should be avoided due to potential risks to the fetus or infant. Patients planning pregnancy should consult their physician for appropriate management.
Precautions & Warnings
Close monitoring is advised during initial treatment, especially for the risk of hypoglycemia. Patients with specific medical conditions, such as G6PD deficiency or hypothyroidism, should use this tablet with caution and under medical supervision.
Use in Special Populations
Special consideration is needed for pediatric use and in patients with renal impairment. Dosage adjustments may be necessary based on renal function to minimize the risk of adverse effects.
Overdose Effects
Overdose of this tablet may lead to severe hypoglycemia or lactic acidosis, necessitating immediate medical attention and appropriate management.
Therapeutic Class
This tablet belongs to the class of combination oral hypoglycemic preparations, providing a comprehensive approach to managing diabetes.
Storage Conditions
Store this tablet in a cool, dry place, away from light, to maintain its stability and effectiveness.
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