Reset 500

Indications

Reset is recommended for various conditions, including fever, common cold, influenza, headache, toothache, earache, body aches, myalgia, neuralgia, dysmenorrhea, sprains, colic pain, back pain, post-operative pain, postpartum pain, inflammatory pain, and post-vaccination pain in children. It is also effective for rheumatic and osteoarthritic pain, as well as joint stiffness.

Always use as directed by a registered healthcare professional.

Pharmacology

Reset contains paracetamol, known for its analgesic and antipyretic properties, with minimal anti-inflammatory effects. It primarily works within the central nervous system (CNS) by increasing pain thresholds through inhibition of cyclooxygenase enzymes (COX-1, COX-2, and COX-3), which are essential for prostaglandin synthesis. Paracetamol is recognized as one of the safest and fastest-acting analgesics, well-tolerated and free from the side effects commonly associated with aspirin.

Dosage & Administration

Tablets:

• Adults: 1-2 tablets every 4 to 6 hours, not exceeding 4 g (8 tablets) daily.
• Children (6-12 years): ½ to 1 tablet 3 to 4 times daily; maximum of 2.6 g/day for long-term use.

Extended Release Tablets:

• Adults & Children over 12 years: 2 tablets every 6 to 8 hours, with a maximum of 6 tablets in 24 hours. Do not crush the tablets.

Syrup/Suspension:

• Children under 3 months: 10 mg/kg body weight (5 mg/kg if jaundiced) 3 to 4 times daily.
• 3 months to 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
• 1-5 years: 1-2 teaspoonfuls 3 to 4 times daily.
• 6-12 years: 2-4 teaspoonfuls 3 to 4 times daily.
• Adults: 4-8 teaspoonfuls 3 to 4 times daily.

Suppositories:

• Children 3-12 months: 60-120 mg, 4 times daily.
• Children 1-5 years: 125-250 mg, 4 times daily.
• Children 6-12 years: 250-500 mg, 4 times daily.
• Adults & Children over 12 years: 0.5-1 g, 4 times daily.

Paediatric Drops:

• Children up to 3 months: 0.5 ml (40 mg).
• 4 to 11 months: 1.0 ml (80 mg).
• 1 to 2 years: 1.5 ml (120 mg). Do not exceed 5 doses daily for a maximum of 5 days.

Paracetamol with Actizorb technology dissolves five times faster than standard tablets, providing rapid analgesic and antipyretic effects. This formulation is especially suitable for individuals who cannot tolerate aspirin or other analgesics.

Interaction

Patients taking barbiturates, tricyclic antidepressants, or alcohol may have reduced ability to metabolize large doses of Reset. Alcohol can increase the risk of hepatotoxicity in cases of overdose. Chronic use of anticonvulsants or oral contraceptives may interfere with therapeutic levels due to enhanced liver metabolism.

Contraindications

Reset is contraindicated in individuals with known hypersensitivity to paracetamol.

Side Effects

Most side effects of Reset are mild; however, some hematological reactions such as thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Occasionally, pancreatitis, skin rashes, and other allergic reactions may occur.

Pregnancy & Lactation

Epidemiological studies indicate no adverse effects from paracetamol when used at recommended dosages during pregnancy, but patients should consult their doctor. Paracetamol is excreted in breast milk in minimal amounts, and breastfeeding is generally considered safe while taking this medication.

Precautions & Warnings

Caution is advised when administering Reset to patients with severe renal or hepatic impairment. The risk of overdose is higher in those with non-cirrhotic alcoholic liver disease. Patients should not exceed the prescribed dosage and should avoid concurrent use of other Reset-containing products.

Overdose Effects

Taking 10 g or more of Reset may result in liver damage. Ingesting 5 g or more can lead to liver injury, especially if combined with certain risk factors. Early symptoms of overdose may include pallor, nausea, vomiting, anorexia, and abdominal pain, with liver damage potentially becoming evident 12 to 48 hours post-ingestion. Immediate medical attention is essential, with activated charcoal treatment considered within the first hour of overdose.

Therapeutic Class

Non-opioid analgesics

Storage Conditions

Store in a cool, dry place, protected from light and heat. Keep out of reach of children.