Reducid 20

Indications

Reducid is prescribed for the management of:

• Gastric ulcers
• Duodenal ulcers
• Anastomotic ulcers
• Acute stress ulcers
• Reflux esophagitis
• Zollinger-Ellison syndrome

Additionally, it is effective in treating acute gastritis and chronic gastritis during periods of acute exacerbation.
For proper usage, consult a registered healthcare provider.

Pharmacology

Famotidine, the active ingredient in Reducid, is a histamine H2-receptor antagonist. It works by fully blocking histamine’s action on the H2 receptors of parietal cells in the stomach, thus reducing gastric acid secretion, whether it’s basal, overnight, or pentagastrin-stimulated. The effects of Famotidine on the H2 receptors are slowly reversible, as the drug dissociates gradually from the receptor sites.

Dosage and Administration

Tablets:

For the treatment of gastric ulcer, duodenal ulcer, anastomotic ulcer, upper gastrointestinal hemorrhage, reflux esophagitis, and Zollinger-Ellison syndrome, the typical adult dosage is:

• Famotidine 20 mg twice daily (after breakfast and supper or before bedtime), or
• Famotidine 40 mg once daily at bedtime.

For acute gastritis and chronic gastritis in acute exacerbation, the standard adult dosage is:

• Famotidine 20 mg twice a day (morning and evening, or before bedtime), or
• Famotidine 40 mg once daily at bedtime, adjusted according to age and symptoms.
  Most ulcer patients typically experience healing within 4-8 weeks. For maintenance, the recommended dose is 20 mg once daily or as directed by a healthcare professional.

Powder for Suspension:

For Gastroesophageal Reflux Disease (GERD), the dosing for infants and children is as follows:

• Infants under 1 year: 0.5 mg/kg once daily, up to 8 weeks.
• Infants 3 to 11 months: 0.5 mg/kg twice daily, up to 8 weeks.
• Infants 1 to 2 months: 0.5 mg/kg once daily, up to 8 weeks.
• Neonates: 0.5 mg/kg once daily, up to 8 weeks.

For children aged 1-16 years:

• GERD: 1 mg/kg/day divided into two doses, up to 40 mg twice daily.
• Duodenal Ulcer and Peptic Ulcer: 0.5 mg/kg/day at bedtime or divided doses up to 40 mg/day.
• Maintenance therapy: 40 mg at bedtime.
• Reflux Esophagitis: 2 mg/kg/day.
• Zollinger-Ellison Syndrome: 40 mg three times daily.

Always follow the guidance of a registered healthcare provider.

Drug Interactions

No significant drug interactions have been identified with Reducid. It does not interact with the cytochrome P450 enzyme system responsible for drug metabolism.

Contraindications

Reducid should not be used in patients who have a known hypersensitivity to any of its components.

Potential Side Effects

Common side effects may include:

• Skin eruptions
• Constipation or diarrhea
• Dry mouth
• Nausea or vomiting
• Tachycardia
• Elevated blood pressure
• Headache
• Drowsiness or insomnia (rare)

Pregnancy and Lactation

Reducid belongs to Pregnancy Category B. While there are no well-controlled studies in pregnant women, it should only be used during pregnancy if deemed necessary by a healthcare provider. Caution should be exercised when administering Famotidine to breastfeeding mothers.

Precautions and Warnings

Use Reducid with caution in elderly patients and those with renal or hepatic impairments. It is advised to administer the drug at the minimum effective dose required for treating the condition.

Storage Recommendations

Store Reducid at temperatures below 30°C, away from direct light and moisture. Keep out of the reach of children.