Purifen 200

Indications

Purifen is used for:

• Relieving symptoms of osteoarthritis.
• Treating rheumatoid disorders, including osseous rheumatism, ankylosing spondylitis, juvenile arthritis, muscular rheumatism, and degenerative joint diseases.
• Providing acute relief for painful menstruation (primary dysmenorrhea).
• Alleviating common headaches and fever.
• Managing mild to moderate pain, such as muscle pain, headaches, and dental discomfort.
• Serving as an adjunct therapy for cold and flu symptoms associated with headaches.

Consult a registered healthcare professional before using this medication.

Pharmacology

Dexibuprofen, the active enantiomer of ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID) known for its analgesic effects. It works by inhibiting prostaglandin synthesis, thus reducing inflammation and pain.

Pharmacokinetics: Primarily absorbed in the small intestine, Dexibuprofen undergoes metabolic transformation in the liver. It is predominantly excreted by the kidneys, with a half-life of 1.8-3.5 hours and about 99% plasma protein binding. Food intake can delay peak plasma concentration but does not affect overall absorption.

Dosage & Administration

• Adults: The recommended dose is 600-900 mg per day in 2-3 divided doses. For acute conditions, doses may temporarily increase to 1200 mg per day.
• Dysmenorrhea: Suggested dosage ranges from 600 to 900 mg per day, divided.

Consult a registered healthcare professional before using this medication.

Interactions

Purifen may interact with various medications, including anticoagulants, lithium, ACE inhibitors, and other NSAIDs. Adjustments to the Dexibuprofen dosage may be necessary when taken with liver enzyme inducers or inhibitors.

Contraindications

Dexibuprofen is contraindicated in individuals with a history of hypersensitivity to the drug, asthma attacks induced by NSAIDs, active gastrointestinal bleeding, Crohn’s disease, severe heart disease, and significant kidney or liver impairment.

Side Effects

Common side effects may include dyspepsia, diarrhea, fatigue, headache, nausea, vomiting, and hypersensitivity reactions, such as bleeding and ulcers.

Pregnancy & Lactation

• Pregnancy: While animal studies show no teratogenic effects, use during pregnancy is generally advised against, especially in late pregnancy due to potential fetal risks.
• Lactation: Dexibuprofen may pass into breast milk; caution is advised for nursing mothers.

Precautions & Warnings

Special monitoring is necessary for patients with asthma, hepatic, renal, or cardiac issues, as well as those with a history of gastrointestinal disorders or allergies.

Use in Special Populations

• Hepatic Impairment: Initiate treatment with lower doses and monitor closely.
• Renal Impairment: Begin with reduced dosages in patients with mild to moderate kidney function impairment.
• Children: Not approved for use in those under 18 in the UK, though some countries permit use in older children.
• Elderly: Start with the lowest effective dose, increasing only if well tolerated.

Overdose Effects

Toxicity is low, with symptoms occurring at high doses. Treatment is symptomatic, with activated charcoal recommended in severe cases. Dialysis is generally ineffective due to strong plasma protein binding.

Therapeutic Class

NSAIDs for osteoarthritis and rheumatoid arthritis.

Storage Conditions

Store below 30°C, away from light, and out of reach of children.