Permisol Max

Indications:

This lotion is specifically designed to treat scabies and pruritus (itching), providing effective relief.

Instructions

• Preparation: After a bath, ensure that the skin is completely dry.
• For Children under 2 years: Apply Permethrin cream carefully around the neck, ears, scalp, and face. For the lotion, apply it evenly to the entire body, avoiding the face and eyes.
• For Adults and Children Over 2 years: Apply the cream to areas like between fingers and toes, under nails, body folds, and genital areas, ensuring it’s absorbed. When using lotion, apply from the neck down to the soles of the feet.
• Washing: After 8-24 hours, thoroughly wash the body with soap and hot water. If washed off earlier than 8 hours, reapply.
• Repeat Application: If necessary, follow the same process after 7 days, under medical guidance.

Always consult with a registered healthcare provider before using this medication.

Pharmacological Information:

Permethrin is a pyrethroid-based scabicide and pediculocide. It works by causing paralysis and death of pests through inhibiting sodium ion influx across nerve cell membranes, delaying repolarization. Crotamiton also acts as a scabicide and antipruritic, effective against Sarcoptes scabei, the scabies mite, and it serves as an effective pediculocide as well.

Dosage:

• Adults & Children Over 2 Years: Apply Permethrin & Crotamiton lotion to the clean, dry skin, avoiding the head and face. Focus on areas like the fingers, toes, wrists, armpits, genital region, breasts, and buttocks. Avoid applying near the eyes and mouth.
• Elderly: Use the lotion over the entire body, including the neck, ears, face, and scalp. Be cautious around the eyes.
• Children Under 2 Years: Application should only be done under medical supervision. Use the lotion across the entire body, excluding the eyes and mouth area.
• Post-Application Care: Leave the lotion on for at least 8 hours. If hands are washed within 8 hours, reapply the lotion. After 8-12 hours, wash the entire body thoroughly.

Consult a registered healthcare provider for personalized dosage recommendations.

Administration:

• Apply the lotion to clean, dry skin. Avoid applying right after a hot bath or if the skin is overheated.
• After 8-12 hours, wash the body thoroughly. Clean all clothes and bedding with hot water to remove any traces of lotion.
• To prevent re-infestation, other family members should apply the lotion as a preventive measure.
• Important: Avoid contact with the eyes and mouth area to prevent irritation.

Interactions:

Avoid using corticosteroids for eczema-like reactions before treatment with Permethrin, as it may worsen scabies by lowering the immune response to the mites. The risk of adverse interactions with corticosteroids is minimal, though.

Contraindications:

Permethrin 5% and Crotamiton 10% should not be used by individuals with known hypersensitivity to either component.

Warnings & Precautions:

• Keep the lotion out of children’s reach.
• Use only externally; avoid direct eye contact, as it may cause irritation.
• Healthcare professionals applying this lotion may wish to wear gloves to prevent hand irritation.

Side Effects:

Common side effects may include a mild, brief burning or stinging sensation, especially in severe scabies cases. Skin irritation symptoms like rash, itching, and erythema can occur as part of the natural scabies cycle.

Pregnancy & Lactation:

• There is insufficient data on the safety of Permethrin & Crotamiton during pregnancy, particularly in the first trimester. It is generally not recommended during pregnancy.
• It is unknown whether the active ingredients pass into breast milk. Nursing mothers should avoid applying the lotion near the nipple area.

Overdose Effects:

• There are no significant reports of overdose; however, excessive application may cause local skin reactions.
• In case of accidental ingestion by a child, consider gastric lavage if within 2 hours.
• Treatment for hypersensitivity reactions should be symptomatic.

Therapeutic Class:

Local antipruritic and parasiticidal preparations.

Storage Conditions:

Store in a cool place (below 25°C) and shield from light. Do not freeze.