Osartil Plus 50

100.00৳ Strip

  • Osartil Plus is an antihypertensive medication that treats high blood pressure and reduces stroke risk.
  • Combines Losartan, an angiotensin II receptor blocker, with Hydrochlorothiazide, a thiazide diuretic.
  • Works synergistically to manage blood pressure and enhance cardiovascular health.
  • Always consult a healthcare professional before use.
Brand

Incepta Pharmaceuticals Ltd

Generics

Losartan Potassium + Hydrochlorothiazide

Type

Tablet

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Description

Indications

Osartil Plus is indicated for managing hypertension and reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Consult a registered healthcare professional before use.

Pharmacology

Osartil Plus combines Losartan and Hydrochlorothiazide. Losartan, an angiotensin II receptor blocker, inhibits the vasoconstrictor effects of angiotensin II, reducing blood pressure and preventing aldosterone secretion. Hydrochlorothiazide is a thiazide diuretic that increases sodium and chloride excretion, reducing plasma volume and indirectly enhancing the effectiveness of Losartan. This combination effectively manages hypertension while addressing electrolyte balance.

Dosage

Hypertension:

  • The usual starting dose is one Osartil Plus tablet (50/12.5 mg) taken once daily.
  • If blood pressure is not adequately controlled, the dosage may be increased to one tablet (100/25 mg) once daily.
  • For hypertensive patients with left ventricular hypertrophy, the initial dose is 50/12.5 mg, which can be adjusted as needed, with a maximum of 100/25 mg once daily.
  • The antihypertensive effect typically manifests within three weeks.

Severe Hypertension:

  • The starting dose for severe hypertension is one tablet (50/12.5 mg) daily, which can be increased to 100/25 mg once daily if necessary.

Consult a registered healthcare professional before use.

Administration

Osartil Plus can be taken with or without food and may be used alongside other antihypertensive medications.

Consult a registered healthcare professional before use.

Interaction

Losartan exhibits minimal pharmacokinetic interactions with Hydrochlorothiazide, Digoxin, Warfarin, and others. However, co-administration with potassium-sparing diuretics or supplements may increase serum potassium levels. The antihypertensive effect can be reduced by non-steroidal anti-inflammatory drugs like indomethacin.

Contraindications

Osartil Plus is contraindicated in individuals with hypersensitivity to any components or with anuria. It should also be avoided in patients with hypersensitivity to sulfonamide-derived drugs.

Side Effects

Common side effects are generally mild and may include dizziness, symptomatic hypotension, and hyperkalemia. Rarely, serious effects such as angioedema, gastrointestinal disturbances, and renal impairment may occur.

Pregnancy & Lactation

Angiotensin II receptor antagonists like Osartil Plus should be avoided during pregnancy due to potential adverse effects on fetal and neonatal health. Limited information is available regarding breastfeeding; alternatives with established safety profiles are recommended.

Precautions & Warnings

  • Monitor for hypersensitivity reactions and electrolyte imbalances.
  • Caution is advised in patients with renal impairment or symptomatic hypotension.

Use in Special Populations

  • Renal Impairment: Dosage can follow the usual regimen if creatinine clearance is >30 ml/min. Loop diuretics are preferred for severe renal impairment.
  • Hepatic Impairment: Not recommended for titration due to dosage limitations.
  • Pediatric Patients: Safety and efficacy in children have not been established.

Overdose Effects

Overdose may result in hypotension and tachycardia. Supportive treatment is recommended. Neither Losartan nor Hydrochlorothiazide is effectively removed by hemodialysis.

Therapeutic Class

Combined antihypertensive preparations.

Storage Conditions

Store below 30°C and keep out of reach of children.

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