Ornova 10

Indications

Ornova is prescribed for the treatment of:

• Gastric and duodenal ulcers
• Reflux esophagitis
• Prevention of ulcer recurrence during low-dose aspirin or NSAID therapy
• Adjunct treatment for Helicobacter pylori eradication in cases of gastric ulcers, duodenal ulcers, MALT lymphoma, idiopathic thrombocytopenic purpura, post-endoscopic resection of early-stage gastric cancer, or Helicobacter pylori gastritis.

Always follow a doctor’s advice for medication use.

Pharmacology

Vonoprazan is a potassium-competitive acid blocker (P-CAB) that does not require activation by acid. It inhibits gastric acid secretion by competitively blocking H+, K+-ATPase in gastric parietal cells. With its strong basicity, it binds to acid-producing sites for a prolonged duration, providing effective protection against mucosal damage in the gastrointestinal tract.

Dosage

• Gastric and Duodenal Ulcer: 20 mg once daily for 6-8 weeks.
• Reflux Esophagitis: 20 mg once daily for up to 8 weeks.
• Maintenance Therapy for Reflux Esophagitis: 10 mg daily, increasing to 20 mg if needed.
• Prevention During Low-Dose Aspirin or NSAID Use: 10 mg daily.
• Helicobacter Pylori Eradication: 20 mg Vonoprazan, 750 mg amoxicillin, and 200 mg clarithromycin twice daily for 7 days.

Follow your doctor’s instructions for appropriate dosage.

Administration

Ornova can be taken with or without food.

Contraindications

• Hypersensitivity to Vonoprazan or its ingredients.
• Co-administration with atazanavir, nelfinavir, or rilpivirine.

Side Effects

Possible side effects include diarrhea, constipation, drug hypersensitivity, jaundice, liver function changes, rash, nausea, and abdominal discomfort.

Pregnancy & Lactation

Use during pregnancy only when the benefits outweigh the risks. Avoid using Vonoprazan in nursing mothers unless absolutely necessary.

Precautions & Warnings

• Monitor the patient regularly during treatment, especially for long-term use.
• Use lower doses or discontinue treatment if the risk of recurrence is low.
• Caution is advised for elderly patients and those with liver or kidney impairment.

Special Populations

• Elderly: Use cautiously due to reduced hepatic or renal function.
• Children: Not recommended for use in children under 18.
• Renal Impairment: No dose adjustment for mild to moderate impairment; avoid in severe impairment.
• Hepatic Impairment: Avoid in moderate to severe liver dysfunction.

Overdose Effects

There is no specific antidote for an overdose. Symptomatic and supportive treatment is recommended.

Therapeutic Class

Potassium Competitive Acid Blocker (P-CAB)

Storage Conditions

Store below 30°C in a dry, cool place. Keep out of reach of children and avoid direct sunlight.