Oricox 60

Indications

Oricox is recommended for the relief of symptoms associated with:

• Osteoarthritis (OA)
• Rheumatoid arthritis (RA)
• Ankylosing spondylitis
• Pain and inflammation related to acute gouty arthritis
• Moderate pain after dental surgery (short-term treatment)

Note: Always follow the advice of a registered healthcare provider before using this medication.

Pharmacology of Oricox

Oricox contains Etoricoxib, a highly effective oral cyclooxygenase-2 (COX-2) inhibitor that works within and above the therapeutic dose range. The COX-2 enzyme primarily contributes to the production of prostanoids responsible for pain, inflammation, and fever, making Etoricoxib an essential treatment for inflammatory conditions. Unlike non-selective NSAIDs, Etoricoxib selectively inhibits COX-2, minimizing gastrointestinal side effects and platelet aggregation issues. Even at doses as high as 150 mg per day, Etoricoxib does not inhibit COX-1, thus sparing the protective effects of COX-1 on the stomach.

Dosage & Administration

For Adults and adolescents over 16 years:

• Osteoarthritis: Start with 30 mg daily. If symptoms persist, increasing to 60 mg daily may be more effective.
• Rheumatoid arthritis: The recommended dose is 90 mg daily.
• Ankylosing spondylitis: 90 mg daily.
• Acute gouty arthritis: 120 mg daily for a maximum of 8 days.
• Postoperative dental surgery pain: 90 mg daily for up to 3 days.

Patients with cardiovascular concerns should use the lowest effective dose for the shortest duration.

Important: Always follow the guidance of a registered medical professional.

Interactions

• With Other Medications:
  • Oral anticoagulants (e.g., warfarin): May increase prothrombin time.
  • Diuretics, ACE inhibitors, and Angiotensin II Antagonists: NSAIDs can reduce their effectiveness.
  • Acetylsalicylic Acid (Low-dose for cardiovascular prevention): Can be taken with Oricox.
  • Ciclosporin and Tacrolimus: May heighten nephrotoxic effects.
  • Lithium: May increase plasma lithium levels.
• With Food: Can be taken with or without meals.

Contraindications

Oricox should not be used if you have:

• Allergies to Etoricoxib or any ingredient.
• Active peptic ulcers or gastrointestinal bleeding.
• Previous allergic reactions to NSAIDs (e.g., asthma, rhinitis, urticaria).
• Severe liver or kidney dysfunction.
• Pregnancy, breastfeeding, or attempting to conceive.
• Certain cardiovascular conditions, including congestive heart failure and high blood pressure.

Side Effects

Common side effects include palpitations, fatigue, influenza-like symptoms, ecchymosis, dry mouth, taste disturbances, and mouth ulcers. Less frequently, it may cause chest pain, anxiety, myalgia, or confusion. If any severe reactions occur, contact your doctor immediately.

Pregnancy & Lactation

Etoricoxib use is not recommended during pregnancy or breastfeeding. It may affect fetal development and can be excreted in breast milk, posing a risk to nursing infants.

Precautions & Warnings

• Use cautiously in elderly patients and those with a history of gastrointestinal issues.
• Monitor cardiovascular health and renal function, especially in patients with hypertension or heart disease.
• Be vigilant for any signs of liver dysfunction or hypersensitivity reactions such as skin rashes or mucosal lesions.
• Oricox may mask symptoms of infection and inflammation, so caution is advised when used with anticoagulants like warfarin.

Overdose Effects

In case of overdose, Oricox is generally well tolerated. Standard supportive measures such as removing unabsorbed material and monitoring the patient may be required. Toxicity from doses up to 500 mg has not been observed.

Therapeutic Class

Oricox belongs to the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class.

Storage

Store below 30°C in a dry, cool place, away from direct light. Keep out of reach of children.