Noteron

Indications

Noteron is indicated for the following conditions:

• Metropathia hemorrhagica (dysfunctional uterine bleeding)
• Premenstrual syndrome
• Postponement of menstruation
• Endometriosis
• Menorrhagia

Always consult a registered healthcare professional before using this medication.

Pharmacology

Noteron contains Norethisterone, a synthetic progestogen that mimics the effects of progesterone. It serves as a potent inhibitor of ovulation and exhibits weak estrogenic and androgenic properties. This medication is effective in treating various menstrual cycle disorders. Norethisterone is well absorbed from the gastrointestinal tract, with effects lasting at least 24 hours, and is excreted via urine.

Dosage & Administration

For oral use only. Not intended for children.

• Dysfunctional uterine bleeding: Take 1 tablet three times daily for 10 days. Bleeding typically resolves within 1-3 days, with withdrawal bleeding resembling a normal period occurring 2-4 days after stopping treatment.
• Prophylaxis against recurrent dysfunctional bleeding: If normal ovarian function does not resume, take 1 tablet twice daily from days 19 to 26 of the cycle.
• Premenstrual syndrome: For symptoms like headaches, breast discomfort, and mood changes, take 2-3 tablets daily from days 19 to 26 of the cycle. Repeat for several cycles as needed.
• Postponement of menstruation: To delay menstruation, take 1 tablet three times daily starting 3 days before the expected period. A normal period should occur 2-3 days after discontinuation.
• Endometriosis: Begin treatment on day 5 of the cycle with 2 tablets daily for the first few weeks. Increase to 4 or 5 tablets daily if spotting occurs. Continue for 4-6 months or longer if necessary.
• Menorrhagia: Take 1 tablet 2-3 times daily from days 19 to 26 of the cycle.

Always consult a registered healthcare professional before using this medication.

Interactions

Currently, no known interactions.

Contraindications

Not suitable for individuals with:

• Pregnancy
• Severe liver dysfunction
• Dubin-Johnson syndrome
• Rotor syndrome
• Existing or previous liver tumors
• History of idiopathic jaundice, severe itching, or herpes gestationis during pregnancy
• Active thromboembolic events
• Hypersensitivity to Norethisterone or any excipients

Side Effects

Side effects may be more pronounced during the initial months of treatment but typically decrease over time. Possible side effects include:

• Visual disturbances
• Nausea
• Headaches and edema
• Migraines
• Dyspnea
• Skin reactions such as rashes or urticaria

Pregnancy & Lactation

Norethisterone is contraindicated during pregnancy and breastfeeding.

Precautions & Warnings

Users of hormonal contraceptives may have an increased risk of thromboembolic events. Although Noteron does not contain estrogen, be cautious in patients with a history of thromboembolic disease or severe diabetes with vascular complications.

In rare cases, benign or malignant liver tumors have been reported. If severe abdominal pain, liver enlargement, or signs of intra-abdominal hemorrhage occur, consider the possibility of a liver tumor and discontinue use if necessary. Regular monitoring of carbohydrate metabolism is advised for diabetic patients.

Immediate Discontinuation Reasons

Stop Noteron if you experience:

• New or worsening migraine headaches
• Sudden vision or hearing disturbances
• Symptoms of thrombophlebitis or chest pain
• Upcoming surgeries or prolonged immobility
• Jaundice or severe itching
• Significant blood pressure increase
• Pregnancy

Overdose Effects

No specific reports of overdose have been documented, and treatment is usually unnecessary. There are no specific antidotes; provide symptomatic care as needed.

Therapeutic Class

Medications for menopausal symptoms: Hormone replacement therapy, Female sex hormones, Oral contraceptive preparations.

Storage Conditions

Store below 30°C in a cool, dry place, and keep out of reach of children.