Norestin 5

Indications for Norestin

Norestin is prescribed for various gynecological conditions, including:

• Dysfunctional uterine bleeding (Metropathia hemorrhagic)
• Premenstrual syndrome (PMS)
• Delaying menstruation
• Endometriosis
• Heavy menstrual bleeding (Menorrhagia)

Pharmacological Profile

Norestin contains Norethisterone, a synthetic progestin with effects similar to progesterone. It is a potent ovulation inhibitor with minimal estrogenic and androgenic properties. Norethisterone is absorbed through the gastrointestinal tract, providing effects for at least 24 hours, and is eventually excreted in the urine.

Dosage and Administration

Norestin is administered orally and is not suitable for children.

• Dysfunctional Uterine Bleeding: Take 1 tablet three times daily for 10 days. Bleeding typically ceases within 1-3 days, with withdrawal bleeding occurring within 2-4 days after stopping the medication.
• Preventing Recurrence of Dysfunctional Bleeding: If ovarian function does not normalize (indicated by the absence of a rise in the second half of the cycle’s morning temperature), recurrence is likely. Administer 1 tablet twice daily from the 19th to the 26th day of the cycle to establish cyclical bleeding.
• Premenstrual Syndrome (Including Premenstrual Mastalgia): For symptoms such as headaches, migraines, breast tenderness, fluid retention, tachycardia, and psychological issues, take 2-3 tablets daily from the 19th to the 26th day of the cycle. Treatment may be repeated for several cycles, with potential symptom relief lasting for several months after discontinuation.
• Menstruation Postponement: To delay menstruation due to frequent bleeding or special circumstances (e.g., surgery, travel), start 1 tablet three times daily, 3 days before the expected onset of menstruation. Menstruation should resume 2-3 days after stopping the medication.
• Endometriosis (Pseudo-Pregnancy Therapy): Begin treatment on the 5th day of the cycle with 2 tablets daily for the initial weeks. If spotting occurs, increase the dosage to 4 or 5 tablets daily. Once bleeding subsides, return to the initial dose. The treatment duration is typically 4-6 months, but may be extended if needed.
• Menorrhagia: Take 1 tablet 2-3 times a day from the 19th to the 26th day of the cycle, counting the first day of menstruation as day 1.

Always follow your healthcare provider’s instructions when using this medication.

Interactions

No known interactions.

Contraindications

Do not use Norestin if you have:

• Pregnancy
• Severe liver dysfunction
• Dubin-Johnson syndrome
• Rotor syndrome
• Liver tumors (past or present)
• History of idiopathic jaundice, severe itching, or herpes gestationis during pregnancy
• Current thromboembolic conditions
• Allergic reactions to Norethisterone or any excipients

Side Effects

Common side effects during the initial treatment phase include:

• Eye disorders: Visual disturbances
• Gastrointestinal issues: Nausea
• General disorders: Headaches, edema
• Nervous system issues: Migraines
• Respiratory issues: Shortness of breath
• Skin reactions: Rash, hives

Pregnancy and Lactation

Norethisterone is contraindicated during pregnancy and should not be used while breastfeeding.

Precautions and Warnings

Although Norestin does not contain estrogen, users should be aware of the potential increased risk of thromboembolic events, particularly if there is a history of such conditions or severe diabetes with vascular changes. Rare cases of benign and malignant liver tumors have been reported, which could lead to serious complications. Monitor for symptoms such as severe abdominal pain, liver enlargement, or signs of bleeding.

Discontinue Norestin immediately if you experience:

• New or worsening migraines
• Sudden vision or hearing disturbances
• Symptoms of thrombophlebitis or embolism, such as chest pain
• Anticipated surgery (discontinue six weeks prior) or immobilization
• Jaundice, hepatitis, or significant itching
• Significant blood pressure increase
• Pregnancy

Overdose

No specific antidote for overdose exists. Treatment should be symptomatic if necessary.

Therapeutic Class

Norestin falls under the category of drugs for menopausal symptoms, hormone replacement therapy, female sex hormones, and oral contraceptives.

Storage

Store below 30°C in a cool, dry place. Keep out of reach of children.