Nitazox Suspension 30ml

Indications

Nitazox is primarily prescribed for the management of diarrhea resulting from infections caused by Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica.
Always follow the advice of a registered healthcare professional when taking this medication.

Pharmacology

Nitazoxanide is a synthetic antiprotozoal agent intended for oral use. Its antiprotozoal properties stem from its ability to inhibit the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependent electron transfer reaction, which is vital for the anaerobic energy metabolism of protozoa. Both Nitazoxanide and its active metabolite, tizoxanide, have demonstrated effectiveness in vitro against the growth of Cryptosporidium parvum sporozoites and Giardia lamblia trophozoites.

Dosage & Administration

• For children aged 1-3 years: Administer 1 teaspoonful (5 ml) of suspension every 12 hours for 3 days.
• For children aged 4-11 years: Administer 2 teaspoonfuls (10 ml) of suspension every 12 hours for 3 days.
• For individuals aged 12 years and older: Administer 5 teaspoonfuls (25 ml) of suspension or 1 tablet every 12 hours for 3 days.

Note: It is advisable to take this medication with food.
Always consult a registered healthcare professional before use.

Interaction

Nitazoxanide has a high affinity for plasma proteins. Caution is advised when used concurrently with other medications that are also highly protein-bound and possess a narrow therapeutic index.

Contraindications

Nitazoxanide is contraindicated in individuals with known hypersensitivity to Nitazoxanide or any of its components.

Side Effects

Common side effects associated with Nitazoxanide include abdominal pain, vomiting, and headaches. These are generally mild and temporary. Rare side effects may include nausea, loss of appetite, flatulence, increased appetite, swollen salivary glands, elevated creatinine and SGPT levels, itching, rhinitis, sweating, dizziness, and discolored urine.

Pregnancy & Lactation

Nitazoxanide falls under US FDA pregnancy category B. Although animal studies do not always predict human outcomes, this medication should be administered during pregnancy only when absolutely necessary. Nitazoxanide is also known to be excreted in human breast milk; therefore, caution is advised for nursing mothers.

Precautions & Warnings

Use Nitazoxanide with care in patients with liver and biliary disorders, as well as those with kidney issues.

Therapeutic Class

Anti-diarrheal Antiprotozoal

Storage Conditions

Store in a cool, dry place away from light and heat. Keep out of reach of children.