Neurolin CR 82.5

Indications

Neurolin CR serves as a remedy for various conditions, including:

• Alleviating neuropathic pain linked with diabetic peripheral neuropathy (DPN)
• Mitigating postherpetic neuralgia (PHN)
• Serving as an adjunctive therapy for managing partial-onset seizures in patients aged 1 month and above
• Addressing fibromyalgia
• Managing neuropathic pain associated with spinal cord injury

Pharmacology

Pregabalin, a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), exhibits its effects by binding with high affinity to the alpha2-delta site in central nervous system tissues. This interaction is believed to underlie Pregabalin’s anti-nociceptive and antiseizure properties.

Dosage

Dosage recommendations vary depending on the condition being treated. For example:

• For adults with neuropathic pain associated with diabetic peripheral neuropathy, dosing typically starts at 50 mg three times daily, with adjustments made based on efficacy and tolerability.
• For postherpetic neuralgia, the initial dose may be 75 to 150 mg twice daily or 50 to 100 mg thrice daily, with similar adjustments based on response.
• The maximum recommended dose for fibromyalgia is typically 300 to 450 mg daily, initiated at 75 mg twice daily and titrated upwards.

Administration

Pregabalin is administered orally, with or without food. Pregabalin CR tablets are taken after an evening meal and should be swallowed whole, without splitting, crushing, or chewing.

Interactions

Neurolin CR is unlikely to cause significant pharmacokinetic drug interactions. However, caution should be exercised when co-administering with other medications.

Contraindications

Pregabalin is contraindicated in individuals with known hypersensitivity to the drug or its components.

Side Effects

Common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and cognitive difficulties. Pediatric patients may experience increased weight and appetite.

Pregnancy & Lactation

Limited data are available regarding the safety of pregabalin in pregnant women and breastfeeding mothers. Thus, caution is advised.

Precautions & Warnings

Special precautions should be taken in patients with a history of angioedema or hypersensitivity reactions. Monitoring for suicidal thoughts, respiratory depression, and peripheral edema is recommended.

Use in Special Populations

Safety and effectiveness in pediatric patients have not been well-established, and caution is warranted in this population.

Overdose Effects

Signs of overdose may include reduced consciousness, agitation, seizures, and heart block. Supportive care and monitoring are essential in such cases.

Therapeutic Class

Neurolin CR belongs to the class of adjunct and primary anti-epileptic drugs.

Storage Conditions

Store Neurolin CR in a cool, dry place, below 30°C, and keep it protected from light and moisture. Ensure it’s out of reach of children.

Common Questions

Various frequently asked questions regarding Neurolin CR’s usage, dosage, and storage are addressed, offering clarity to users.

Quick Tips

Simple and actionable tips are provided for users, including adherence to prescribed dosage, caution while driving due to potential drowsiness, and monitoring for vision changes or mood-related issues.