Moxquin XG

Indications

This ophthalmic solution is prescribed for the effective treatment of bacterial conjunctivitis caused by susceptible strains of various organisms, including:

Aerobic Gram-Positive Microorganisms:

• Corynebacterium species
• Micrococcus luteus
• Staphylococcus aureus
• Staphylococcus epidermidis
• Staphylococcus haemolyticus
• Staphylococcus hominis
• Staphylococcus warneri
• Streptococcus pneumoniae
• Streptococcus viridans group

Aerobic Gram-Negative Microorganisms:

• Acinetobacter iwoffii
• Haemophilus influenzae
• Haemophilus parainfluenzae

Consult with a registered healthcare professional before using this medication.

Pharmacology

Moxifloxacin exerts its antimicrobial effects by inhibiting two essential enzymes: topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is crucial for the replication, transcription, and repair of bacterial DNA, while topoisomerase IV plays a significant role in the separation of chromosomal DNA during bacterial cell division.

Dosage & Administration

Administer one drop in the affected eye(s) twice daily for a duration of seven days.
Follow your healthcare provider’s recommendations regarding this medication.

Interaction

Studies examining drug interactions with Moxifloxacin Hydrochloride have not been performed.

Side Effects

Common ocular side effects reported in 1-6% of patients include:

• Eye irritation
• Fever
• Conjunctivitis
• Decreased visual acuity
• Dry eyes
• Ocular discomfort
• Ocular hyperemia
• Ocular pain
• Itching
• Subconjunctival hemorrhage
• Tearing

Pregnancy & Lactation

Moxifloxacin should be used during pregnancy only if the potential benefits outweigh any risks to the fetus, as adequate studies in pregnant women are lacking. While Moxifloxacin has not been measured in human breast milk, it is presumed to be excreted. Caution is advised when administering this medication to breastfeeding mothers.

Precautions & Warnings

Extended use of Moxifloxacin may lead to the overgrowth of non-susceptible organisms, including fungi, when combined with other anti-infectives.

Use in Special Populations

• Pediatric Use: The safety and efficacy of Moxifloxacin in infants under four months have not been established. However, clinical studies suggest its safe use in children younger than one month.
• Geriatric Use: No significant differences in safety and efficacy have been noted between elderly and younger patients.

Overdose Effects

The risk of adverse effects from accidental ingestion is minimal, as a 5 ml bottle of this eye drop solution contains only 25 mg of Moxifloxacin, which is significantly lower than the recommended daily oral dosage.

Therapeutic Class

Ophthalmic antibacterial agents

Storage Conditions

Store in a cool, dry place away from light. Keep out of reach of children. Avoid touching the dropper tip to any surfaces to prevent contamination. Discard the dropper one month after first opening.