Moxaclav1.2 IV

Infections Treatable with Co-amoxiclav: Co-amoxiclav effectively treats various bacterial infections in different areas of the body, including:

• Upper Respiratory Tract Infections: Such as tonsillitis, sinusitis, and otitis media.
• Lower Respiratory Tract Infections: Including acute and chronic bronchitis, lobar and bronchopneumonia.
• Genito-urinary Tract Infections: Such as cystitis, urethritis, and pyelonephritis.
• Skin and Soft Tissue Infections
• Bone and Joint Infections: Including osteomyelitis.
• Other Infections: Such as septic abortion, puerperal sepsis, intra-abdominal sepsis, etc.

Composition

• 375 mg Tablet: Contains Amoxicillin 250 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP).
• 625 mg Tablet: Contains Amoxicillin 500 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP).
• 1 gm Tablet: Contains Amoxicillin 875 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP).
• Powder for Suspension: Each 5 ml reconstituted suspension contains Amoxicillin 125 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 31.25 mg (as Diluted Potassium Clavulanate BP).
• Powder for Suspension (Forte): Each 5 ml reconstituted suspension contains Amoxicillin 400 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 57.5 mg (as Diluted Potassium Clavulanate BP).
• 1.2 gm Injection: Each vial contains a sterile mixture of Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg).
• 0.6 gm Injection: Each vial contains a sterile mixture of Amoxicillin Sodium BP (equivalent to Amoxicillin 500 mg) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg).

Pharmacology

Pharmacodynamic Properties: Co-amoxiclav combines Amoxicillin and Clavulanic Acid, effectively combating a broad spectrum of bacteria. While Amoxicillin targets both Gram-positive and Gram-negative microorganisms, Clavulanic Acid prevents degradation of Amoxicillin by beta-lactamase enzymes, extending its effectiveness against resistant microorganisms.

Pharmacokinetic Properties: Peak serum levels of both components occur approximately one hour after oral administration. Absorption is enhanced when taken with food. Doubling the dosage doubles serum levels achieved.

Dosage

For Adults and Children Over 12 Years:

• Tablet: The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours. For severe infections, one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
• Suspension: Dosage varies based on age and severity of infection.

For Children 1 to 12 Years:

• Dosage is weight-based and divided into mild to moderate and serious infections categories.

For IV Injection:

• Dosage varies based on age and severity of infection.

Administration

• Oral dosage form: Can be taken with or without food.
• IV injection: Must be administered intravenously over a specified time period.

Interactions

• Co-amoxiclav may interact with certain medications, caution advised.

Contraindications

• Avoid in patients with known hypersensitivity to penicillin or previous history of Co-amoxiclav-associated cholestatic jaundice.

Side Effects

• Side effects are generally mild and transient, including gastrointestinal symptoms. Rare but serious reactions may occur.

Pregnancy & Lactation

• Use during pregnancy or lactation only if clearly needed and under medical supervision.

Precautions & Warnings

• Caution advised in patients with certain medical conditions. Dosage adjustments may be necessary.

Use in Special Populations

• Dosage adjustments may be needed in patients with renal or hepatic impairment.

Overdose Effects

• Overdose unlikely, but gastrointestinal symptoms may occur.

Therapeutic Class

• Co-amoxiclav belongs to the class of broad-spectrum penicillins.

Reconstitution

• IV injection should be reconstituted as directed and administered cautiously.

Storage Conditions

• Store below 25°C, protect from light and moisture. Follow specific instructions for reconstituted suspension and vial usage.