Indications
Co-amoxiclav is used for the short-term treatment of bacterial infections affecting various areas of the body:
- Upper respiratory tract infections (e.g., tonsillitis, sinusitis, otitis media)
- Lower respiratory tract infections (e.g., acute and chronic bronchitis, pneumonia)
- Genito-urinary tract infections (e.g., cystitis, urethritis, pyelonephritis)
- Skin and soft tissue infections
- Bone and joint infections (e.g., osteomyelitis)
- Other infections (e.g., septic abortion, puerperal sepsis, intra-abdominal sepsis)
Composition
- 375 mg tablet: Contains Amoxicillin 250 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP)
- 625 mg tablet: Contains Amoxicillin 500 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP)
- 1 gm tablet: Contains Amoxicillin 875 mg (as Amoxicillin Trihydrate BP) and Clavulanic Acid 125 mg (as Diluted Potassium Clavulanate BP)
- Powder for Suspension: Contains Amoxicillin 125 mg/5 ml (as Amoxicillin Trihydrate BP) and Clavulanic Acid 31.25 mg/5 ml (as Diluted Potassium Clavulanate BP)
- Powder for Suspension (Forte): Contains Amoxicillin 400 mg/5 ml (as Amoxicillin Trihydrate BP) and Clavulanic Acid 57.5 mg/5 ml (as Diluted Potassium Clavulanate BP)
- Injection: Available in 1.2 gm and 0.6 gm vials for intravenous use
Pharmacology
Co-amoxiclav combines Amoxicillin, a broad-spectrum antibiotic, with Clavulanic Acid, a β-lactamase inhibitor. This combination extends the spectrum of activity against β-lactamase-producing microorganisms, enhancing its effectiveness.
Dosage
For adults and children over 12 years, dosage varies depending on the severity of the infection and formulation used (tablet, suspension, or injection).
Administration
Oral forms can be taken with or without food; however, taking them with a meal can improve absorption, particularly of Clavulanic Acid. Intravenous injections should be administered over specified durations to ensure efficacy and safety.
Interactions
Co-amoxiclav may interact with certain medications, affecting their efficacy. It’s important to discuss all current medications with your healthcare provider.
Contraindications
Patients with a history of hypersensitivity to penicillins or previous jaundice associated with Co-amoxiclav should avoid its use.
Side Effects
Side effects are generally mild and transient, including gastrointestinal symptoms. Severe allergic reactions are rare but possible.
Pregnancy & Lactation
While animal studies show no teratogenic effects, caution is advised in pregnant and lactating women, with use recommended only if clearly needed.
Precautions & Warnings
Special care is needed in patients with certain conditions such as renal impairment or those on anticoagulation therapy.
Storage
Co-amoxiclav should be stored below 25°C, protected from light and moisture, and any reconstituted suspension should be refrigerated and used within a specified timeframe.
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