Montene 5

Indications

Montene serves as a vital medication for the following conditions:

• Prophylaxis and continual treatment of asthma
• Immediate prevention of Exercise-Induced Bronchoconstriction (EIB)
• Alleviation of symptoms related to Allergic Rhinitis (AR): both Seasonal and Perennial Allergic Rhinitis

Pharmacological Insights

Montelukast, a selective and orally active leukotriene receptor antagonist, effectively inhibits the cysteinyl leukotriene receptor (CysLT1). These cysteinyl leukotrienes (LTC4, LTD4, LTE4), derived from arachidonic acid metabolism and released from various cells including mast cells and eosinophils, are central to the pathophysiology of asthma and allergic rhinitis. By impeding leukotriene receptor occupation, Montelukast mitigates airway edema, smooth muscle contraction, and other inflammatory processes contributing to the signs and symptoms of asthma.

Dosage & Administration

For adults and adolescents with asthma or seasonal allergic rhinitis, the recommended dosage is a once-daily intake of Montelukast 10 mg tablet. Pediatric patients are prescribed specific dosages based on their age:

• For those aged 6 to 14 years: Montelukast 5 mg tablet once daily.
• For children aged 2 to 5 years: Montelukast 4 mg tablet once daily.
• For infants aged 6 months to 5 years: Montelukast 4 mg oral granules once daily, either directly in the mouth or mixed with cold water or soft food at room temperature.

Special Considerations

• Hepatic Insufficiency: No adjustment in dosage is necessary for patients with mild-to-moderate hepatic insufficiency.
• Renal Insufficiency: Patients with renal insufficiency do not require dosage adjustment.
• Elderly Patients: The pharmacokinetic profile and oral bioavailability of Montelukast remain consistent across age groups, with slightly longer plasma half-life in the elderly. No dosage adjustment is necessary for this demographic.

Interactions

Montene has been co-administered with various therapies used in asthma treatment without an increase in adverse reactions. In clinical studies, Montene demonstrated no clinically significant effects on the pharmacokinetics of drugs such as theophylline, prednisone, oral contraceptives, terfenadine, digoxin, and warfarin. Though specific interaction studies were not conducted, Montene was safely used alongside a wide range of commonly prescribed medications.

Contraindications

Montelukast is contraindicated in individuals with hypersensitivity to any component of the product.

Side Effects

Common side effects may include diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, and upper respiratory tract infections. Uncommon and rare side effects may occur but are less frequently observed.

Pregnancy & Lactation

While Montelukast crosses the placenta in animal studies, its safety in pregnant women has not been adequately studied. Caution is advised when administering Montelukast to nursing mothers.

Precautions & Warnings

Montene should not be used for the reversal of bronchospasm in acute asthma attacks. Patients should be informed to have rescue medication readily available. Montene can be continued during acute asthma exacerbations, but abrupt substitution for inhaled or oral corticosteroids should be avoided. It should not be used as monotherapy for the treatment of exercise-induced bronchospasm. Patients with known aspirin sensitivity should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking Montene.

Overdose Effects

In reported cases of overdose, adverse experiences were consistent with the known safety profile of Montene. Supportive measures should be employed in the event of overdose, with standard clinical monitoring and appropriate supportive therapy as required.

Therapeutic Class

Montene belongs to the class of leukotriene receptor antagonists.

Storage Conditions

Montene should be stored in a cool and dry place below 30°C, protected from light and moisture, and kept out of reach of children.

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure: Refer to the chemical structure of Montelukast Sodium.

Common Questions about Montene 5 mg Tablet

• What is Montene 5 mg DT? Montene 5 mg DT is a selective and orally active leukotriene receptor antagonist.
• What is Montene 5 mg DT used for? Montene 5 mg DT is commonly used to treat asthma or allergic rhinitis by blocking leukotrienes and keeping airways open.
• How soon can the effect of Montene 5 mg DT be observed? The effect of Montene 5 mg DT can typically be observed within 1-3 hours of administration.
• How long does the effect of Montene 5 mg DT last? Montene 5 mg DT provides relief for approximately 24 hours.
• Should I use Montene 5 mg DT on an empty stomach? Montene 5 mg DT may be taken with or without food, as prescribed by a healthcare professional.
• What if I miss a dose of Montene 5 mg DT? If a dose is missed, it should be taken as soon as possible. However, if it is nearly time for the next dose, skipping the missed dose is recommended to avoid doubling up.
• Are there any pregnancy warnings for Montene 5 mg DT? The use of Montene 5 mg DT in pregnant women should be avoided unless absolutely necessary.

General Instructions

• Montene 5 mg DT should be taken exactly as prescribed by a healthcare provider.
• Patients should not alter the dosage of Montene 5 mg DT or discontinue its use without consulting a healthcare professional.
• Montene 5 mg DT is not intended for rapid relief of asthma attacks; appropriate medical attention should be sought in such cases.
• Patients should avoid triggers that may induce asthma attacks.
• Consultation with a healthcare provider is advised before using Montene 5 mg DT during pregnancy or while breastfeeding.