Mirakof Syrup

Indications

Mirakof serves as a remedy for dry (non-productive) coughs, often stemming from recent viral infections. Additionally, it proves beneficial for managing pre- and post-operative cough sedation in individuals undergoing surgical procedures and bronchoscopy. Its application extends to acute coughs of various origins, including but not limited to whooping cough and coughs associated with acute lower respiratory tract infections such as tracheitis, laryngitis, and bronchitis.

Pharmacology

Butamirate Citrate directly targets the brain’s cough center to alleviate coughing. Distinguished by its safety and non-sedative properties, Butamirate Citrate bears no chemical or pharmacological resemblance to opium alkaloids. Following oral intake, it is swiftly and entirely absorbed. Peak concentration is achieved within 9 hours with sustained-release tablets. Notably, it exhibits high protein binding, and its plasma elimination half-life spans about 13 hours. The active metabolites of Butamirate Citrate also exert antitussive effects.

Dosage & Administration

For Adults:

• Butamirate Citrate 50 mg tablet: 2-3 tablets daily.
• Butamirate Citrate syrup: 15 ml, four times daily.

For Children & Adolescents:

• Butamirate Citrate 50 mg tablet:
  • Adolescents over 12 years old: 1-2 tablets daily.
• Butamirate Citrate syrup:
  • Children (3-6 yrs): 5 ml, three times daily.
  • Children (6-12 yrs): 10 ml, three times daily.
  • Adolescents: 15 ml, three times daily.
• Butamirate Citrate pediatric drops:
  • Children (2 months-1 yr): 0.50 ml, four times daily.
  • Children (1-3 yrs): 0.75 ml, four times daily.

• Use medication as per physician’s advice.

Interaction

Avoid concurrent use with expectorants.

Contraindications

Avoid in case of hypersensitivity to the active ingredient.

Side Effects

Mirakof generally exhibits good tolerance. In rare instances, adverse reactions like rash, nausea, diarrhea, and vertigo may occur, typically resolving with dose adjustment or discontinuation of treatment.

Pregnancy & Lactation

Avoid Butamirate Citrate during the first trimester of pregnancy. Use during subsequent trimesters should be under medical guidance. Caution is advised during breastfeeding due to insufficient data on active substance elimination in breast milk.

Precautions & Warnings

Mirakof suppresses the cough reflex, hence avoid concurrent use with expectorants to prevent mucus retention and reduce the risk of bronchospasm and respiratory infections. Consult a doctor if cough persists beyond 7 days (or 3 days in children under 12 years).

Overdose Effects

Accidental overdose may lead to symptoms such as drowsiness, nausea, vomiting, diarrhea, balance issues, and hypotension. Standard emergency measures include activated charcoal, saline laxatives, and cardio-respiratory resuscitation.

Therapeutic Class

Cough suppressant

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.