Menoral 5

Indications

Menoral is formulated to address the following conditions:

• Metropathia hemorrhagic (dysfunctional uterine bleeding)
• Premenstrual syndrome
• Postponement of menstruation
• Endometriosis
• Menorrhagia

Pharmacology

Menoral contains Norethisterone tablets, which exhibit progestational actions akin to progesterone but with heightened potency in inhibiting ovulation. Additionally, it possesses weak estrogenic and androgenic properties, effectively treating various menstrual cycle disorders. Norethisterone is absorbed from the gastrointestinal tract, ensuring sustained effects lasting at least 24 hours, with excretion occurring in the urine.

Dosage & Administration

Menoral is administered orally and is intended for adult use only.

• Metropathia hemorrhagic (dysfunctional uterine bleeding): Take 1 tablet three times daily for 10 days. Bleeding is typically arrested within 1-3 days, with withdrawal bleeding resembling normal menstruation occurring 2-4 days after discontinuation.
• Prophylaxis against recurrence of dysfunctional bleeding: If signs of normal ovarian function are absent, anticipate recurrence. Establish cyclical bleeding with 1 tablet twice daily from the 19th to the 26th day of the cycle.
• Premenstrual syndrome: Alleviate symptoms by taking 2-3 tablets daily from the 19th to the 26th day of the cycle. Repeat treatment across several cycles for optimal results.
• Postponement of menstruation: Initiate 1 tablet thrice daily, starting 3 days before expected menstruation onset. Normal menstruation typically resumes 2-3 days after stopping treatment.
• Endometriosis: Begin long-term treatment with 2 tablets daily on the 5th day of the cycle, adjusting dosage as needed. Treatment duration spans 4-6 months continuously or longer if required.
• Menorrhagia: Take 1 tablet 2-3 times daily from the 19th to the 26th day of the cycle.

Interactions

No interactions have been reported.

Contraindications

Avoid Menoral during pregnancy, severe liver function disturbances, Dubin-Johnson syndrome, Rotor syndrome, previous or existing liver tumors, history of idiopathic jaundice, severe pruritus, herpes gestationis during pregnancy, current thromboembolic processes, or hypersensitivity to active substances or excipients.

Side Effects

Common side effects may occur during initial months of Menoral usage and diminish with continued treatment. These include visual disturbances, nausea, headache, edema, migraine, and hypersensitivity reactions like rash or urticaria.

Pregnancy & Lactation

Norethisterone usage during pregnancy or lactation is contraindicated.

Precautions & Warnings

Consider potential thromboembolic risks, particularly in patients with a history of thromboembolic disease, severe diabetes with vascular changes, or sickle-cell anemia. Monitor carbohydrate metabolism in diabetic patients before and during treatment. Discontinue Menoral immediately if migrainous headaches worsen, perceptual disorders occur, thrombophlebitis or thromboembolic symptoms arise, jaundice or hepatitis develops, blood pressure rises significantly, or pregnancy is suspected.

Overdose Effects

Overdosage reports are scarce, and treatment is typically unnecessary. No specific antidotes exist; manage symptoms as appropriate.

Therapeutic Class:

Menoral belongs to the therapeutic class of drugs for menopausal symptoms, including hormone replacement therapy, female sex hormones, and oral contraceptive preparations.

Storage Conditions:

Store Menoral below 30°C in a cool, dry place, away from children’s reach.