Indications:
- Insomnia: Melato is used to induce sleep in individuals with disrupted circadian rhythms (e.g., jet lag, night shift workers), low melatonin levels (e.g., elderly, schizophrenia patients), and children with learning disabilities.
- Osteoporosis: Melato stimulates osteoblast cells to promote bone growth.
- Menopause: Helps peri- or postmenopausal women regulate sleep patterns.
- Eating Disorders: Melato levels may influence symptoms of anorexia.
- ADHD: Effective in managing sleep disturbances in children with ADHD.
- Sarcoidosis
Description:
Melato is a hormone produced by the pineal gland that regulates hormones and maintains circadian rhythm. It responds to light intensity, daily changes in light/dark cycles, and seasonal variations. Melato influences sleep, controls timing of female reproductive hormones, and acts as a potent antioxidant to strengthen the immune system.
Pharmacology:
Melato binds to MT1 and MT2 receptors in the brain and peripheral organs, increasing serotonin, GABA, and decreasing dopamine levels to induce and sustain sleep while regulating circadian rhythm.
Dosage & Administration:
- Adults: For insomnia, 3-6 mg one hour before bedtime.
- Jet Lag: 0.5 to 5 mg before bedtime at destination or 1 to 5 mg before bedtime for 2 days prior to departure and upon arrival.
- Sarcoidosis: 20 mg/day for 4-12 months.
- Depression: 0.125 mg twice daily.
- Children (6 months to 14 years): For sleep disorders, 0.3 mg/day.
Interaction:
Melato interacts with antidepressants, antipsychotics, benzodiazepines, blood pressure medications, anticoagulants, NSAIDs, steroids, immunosuppressants, tamoxifen, caffeine, tobacco, alcohol, cocaine, and amphetamines.
Contraindications:
Autoimmune diseases.
Side Effects:
Potential side effects include headache, depression, and drowsiness affecting driving skills.
Pregnancy & Lactation:
Safety and efficacy not established.
Precautions & Warnings:
Caffeine and fluvoxamine may interact with melatonin, affecting its effects.
Overdose Effects:
Minimal evidence of toxicity even at high doses.
Therapeutic Class:
Hormone preparations for other uses, Oral nutritional preparations.
Storage Conditions:
Store below 30°C, away from light, and out of reach of children.
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