Mecolagin

Indications

Mecolagin tablets are indicated for the treatment of:

• Peripheral neuropathy
• Diabetic neuropathy
• Alcoholic neuropathy
• Drug-induced neuropathy
• Entrapment neuropathy
• Lumbago
• Intercostal neuralgia
• Diabetic retinopathy
• Multiple sclerosis
• Vertebral syndrome
• Parkinson’s disease
• Alzheimer’s disease
• Bell’s palsy

Mecolagin Injection is indicated for:

• Treatment of peripheral neuropathies
• Management of megaloblastic anemia due to vitamin B12 deficiency

Please consult a registered healthcare professional before using this medication.

Pharmacology

Mecobalamin is a coenzyme form of vitamin B12, distinguished from cyanocobalamin by the substitution of a methyl group for the cyano group at cobalt. It serves as a cofactor for the enzyme methionine synthase, facilitating the transfer of methyl groups for regenerating methionine from homocysteine. Mecobalamin is essential for maintaining myelin integrity, supporting neuronal function, ensuring proper red blood cell formation, and facilitating DNA synthesis. Additionally, it aids in synthesizing neuronal lipids, regenerating axonal nerves, promoting axonal transport, and exhibiting neuroprotective properties.

Dosage & Administration

Tablets: The recommended dosage is 0.5 mg taken three times daily after meals. Dosage may be adjusted based on the patient’s age and symptom severity.

Injection:

• Peripheral Neuropathies: Adults should receive 1 ampoule (500 mcg Mecobalamin) administered intramuscularly (IM) or intravenously (IV) three times a week. The dosage may be adjusted according to the patient’s age and symptoms.
• Megaloblastic Anemia: Adults should receive 1 ampoule (500 mcg Mecobalamin) daily, administered IM or IV three times a week. After two months of treatment, the dose may be reduced to one ampoule every 1 to 3 months for maintenance therapy.

Use in Children: Not recommended.

Please consult a registered healthcare professional before using this medication.

Interaction

The absorption of vitamin B12 may be diminished by medications such as neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Additionally, oral contraceptives may decrease serum concentrations. While many of these interactions are not clinically significant, they should be considered when evaluating blood concentrations.

Contraindications

Do not use if there is hypersensitivity to Mecobalamin or any components of the formulation.

Side Effects

Dermatological Effects: Rash; discontinue treatment if such symptoms occur.

Gastrointestinal Effects: Anorexia, nausea/vomiting, and diarrhea.

Neurological Effects (Central Nervous System): Headache.

Others:

• Anaphylactoid reactions, such as decreased blood pressure or dyspnea, may occur. Patients should be closely monitored, and treatment should be stopped immediately if symptoms arise.
• Hot sensation
• Diaphoresis
• Pain or induration at the injection site

Pregnancy & Lactation

Data on the use of Mecobalamin during pregnancy and lactation are limited. However, as vitamin B12 is present in breast milk, its use is generally considered compatible with breastfeeding according to the American Academy of Pediatrics.

Precautions & Warnings

Mecolagin should not be used aimlessly for longer than one month unless deemed effective. Prolonged use of higher doses is not recommended for individuals whose occupations involve handling mercury or mercury compounds.

Therapeutic Class

Drugs for Megaloblastic Anemia

Storage Conditions

Store at room temperature, away from moisture and light.