Lopadine DS 0.2%

Indications

Patadin Eye Drops are used to alleviate the symptoms of allergic conjunctivitis, such as itchy, watery, red, and swollen eyes or eyelids. It is particularly effective in treating conditions like vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis, and giant papillary conjunctivitis.
Lopadine DS Nasal Spray is an H1 receptor antagonist formulated to relieve symptoms of seasonal allergic rhinitis in adults and children aged 6 and older.
Lopadine DS Tablets are prescribed for the treatment of allergic rhinitis, caused by allergens like pollen and mold spores, and skin allergies. This includes symptoms like hives, itching, swelling, sneezing, and nasal congestion.
(Use as per your doctor’s advice.)

Pharmacology

Olopatadine is an antihistamine that blocks histamine action in the body, effectively reducing allergy symptoms. It is known to treat sneezing, itching, and runny nose caused by allergies.

Mode of Action:

Olopatadine works as an anti-allergic by stabilizing mast cells and blocking histamine H1 receptors. It prevents the release of inflammatory mediators such as tryptase and prostaglandin D2, reducing allergy symptoms significantly.

Pharmacokinetics:

Absorption: Olopatadine reaches peak plasma concentration between 30 minutes to 1 hour after intranasal administration.
Distribution: It binds moderately to proteins in human serum, independent of drug concentration.
Metabolism: Olopatadine undergoes minimal metabolism, with several minor metabolites circulating in plasma.
Elimination: It has an elimination half-life of 8 to 12 hours and is mainly excreted through urine.

Dosage

Eye Drops:

• 0.1%: Instill one drop in each affected eye, twice daily, with 6-8 hour intervals.
• 0.2%: Instill one drop once a day.
• 0.7%: Instill one drop in each affected eye once daily.

Nasal Spray:

• Adults and children (12 years and older): Two sprays per nostril, twice daily.
• Children (6 to 11 years): One spray per nostril, twice daily.
  (Use as per your doctor’s prescription.)

Tablet:

• Adults: One tablet (5 mg) twice daily, morning and night. Dosage adjustments may be made depending on your age or condition.
• Children (7 years and older): One tablet (5 mg) twice daily, morning and night.
  (If you miss a dose, take it as soon as possible unless it’s near the next scheduled dose. Avoid doubling up doses.)

Administration Instructions

Nasal Spray

• Shake the bottle gently before use.
• Clear your nostrils by blowing your nose.
• Insert the spray nozzle into one nostril, close the other, and spray while inhaling. Repeat for the other nostril if required.
• Clean the nasal spray weekly by washing the applicator in warm water and letting it air dry.

(Use as advised by your healthcare provider.)

Interactions

No formal drug interaction studies have been conducted for Lopadine DS Nasal Spray. Since olopatadine is mainly eliminated through the kidneys, interactions involving liver enzymes are not expected.

Contraindications

Do not use if allergic to any component of this product. Consult your doctor if you have any existing medical conditions or are on other medications to ensure the product is safe for you.

Side Effects

Headaches may occur rarely. Other side effects include blurred vision, dry eyes, sinusitis, and nausea. If any severe side effects develop, discontinue use and contact your doctor.

Pregnancy & Lactation

There is no conclusive evidence of risk in pregnant women, but caution should be exercised. Use only if the benefits outweigh potential risks to the fetus. The effects on breast milk are unknown, so consult your doctor if you are breastfeeding.

Precautions & Warnings

• Avoid using Patadin Eye Drops if your eyes are red. If wearing contact lenses, wait at least 10 minutes after applying the drops before reinserting them.
• Avoid contact with the eyes when using Lopadine DS Nasal Spray.

Special Populations

No significant differences in safety have been observed in elderly patients. Always follow your doctor’s instructions closely.

Overdose Effects

There is no information on Lopadine DS overdose. If an overdose is suspected, seek medical attention immediately.

Therapeutic Class

Ophthalmic non-steroidal drugs.

Storage Conditions

Store in a cool, dry place, away from direct sunlight. The product should not be used more than one month after opening.