Lerozol 2.5

Indications

1. Adjunctive Therapy for Early Breast Cancer in Postmenopausal Women: We offer adjunctive treatment for hormone receptor positive early breast cancer in postmenopausal women.
2. Extended Adjunctive Therapy for Early Breast Cancer: Extended adjunctive therapy is available for postmenopausal women with early breast cancer, including those with positive or unknown hormone receptor status who have completed 5 years of adjuvant tamoxifen therapy.
3. First-Line Treatment for Advanced Breast Cancer: Our pharmacy specializes in first-line treatment options for hormone-dependent advanced breast cancer in postmenopausal women.
4. Advanced Breast Cancer Treatment: We provide treatment for advanced breast cancer in women with natural or induced postmenopausal status, especially those who have previously received antioestrogen therapy.
5. Pre-operative Therapy for Localized Breast Cancer: Pre-operative therapy is offered for localized hormone receptor positive breast cancer in postmenopausal women, aimed at facilitating subsequent breast-conserving surgery.

Pharmacology

Mechanism of Action: Letrozole is a potent aromatase inhibitor that selectively targets estrogen biosynthesis. By competitively binding to the aromatase enzyme, it effectively reduces estrogen levels in tissues, thereby inhibiting the growth of estrogen-dependent breast cancer cells.

Pharmacokinetics: Letrozole is rapidly absorbed and metabolized in the body, with a bioavailability of 99.9%. It exhibits high plasma protein binding and is primarily eliminated through metabolic clearance.

Dosage & Administration

We recommend a daily dose of 2.5 mg of Letrozole for adult and elderly patients. Treatment duration varies based on the clinical setting, ranging from 5 years in the adjuvant setting to continued therapy in metastatic disease. Dosing adjustments are not required for elderly patients or those with hepatic or renal impairment.

Interactions

Clinical interaction studies show that co-administration of Letrozole with drugs like cimetidine and warfarin does not result in clinically significant reactions.

Contraindications

Letrozole is contraindicated in individuals with known hypersensitivity to the drug or its ingredients, as well as in pregnant or lactating women and those with severe hepatic dysfunction.

Side Effects

Common side effects of Letrozole include hot flushes, fatigue, joint pain, and gastrointestinal disturbances.

Pregnancy & Lactation

Due to potential teratogenic effects, Letrozole is not recommended during pregnancy or lactation.

Precautions & Warnings

Patients with moderate hepatic dysfunction should use Letrozole with caution, and renal impairment does not necessitate dose adjustments.

Overdose Effects

While clinical experience with Letrozole overdose is limited, supportive care and monitoring are recommended in such instances.

Therapeutic Class

Letrozole belongs to the therapeutic class of hormonal chemotherapy.

Storage Conditions

We recommend storing Letrozole below 30°C, away from light and moisture, to maintain its stability and efficacy.